Entity Details

Primary name MTOR_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9JLN9
EntryNameMTOR_MOUSE
FullNameSerine/threonine-protein kinase mTOR
TaxID10090
Evidenceevidence at protein level
Length2549
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesMtor

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding
GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding
GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:0001156 TFIIIC-class transcription factor complex binding
GO:0001558 regulation of cell growth
GO:0001932 regulation of protein phosphorylation
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002296 T-helper 1 cell lineage commitment
GO:0003007 heart morphogenesis
GO:0003179 heart valve morphogenesis
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005979 regulation of glycogen biosynthetic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006112 energy reserve metabolic process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006468 protein phosphorylation
GO:0007040 lysosome organization
GO:0007281 germ cell development
GO:0007420 brain development
GO:0007569 cell aging
GO:0007584 response to nutrient
GO:0007616 long-term memory
GO:0008361 regulation of cell size
GO:0008542 visual learning
GO:0009267 cellular response to starvation
GO:0009791 post-embryonic development
GO:0010506 regulation of autophagy
GO:0010507 negative regulation of autophagy
GO:0010592 positive regulation of lamellipodium assembly
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010831 positive regulation of myotube differentiation
GO:0010942 positive regulation of cell death
GO:0010976 positive regulation of neuron projection development
GO:0012505 endomembrane system
GO:0014042 positive regulation of neuron maturation
GO:0014736 negative regulation of muscle atrophy
GO:0014823 response to activity
GO:0016020 membrane
GO:0016242 negative regulation of macroautophagy
GO:0016301 kinase activity
GO:0016310 phosphorylation
GO:0016605 PML body
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0021510 spinal cord development
GO:0030030 cell projection organization
GO:0030425 dendrite
GO:0030838 positive regulation of actin filament polymerization
GO:0031397 negative regulation of protein ubiquitination
GO:0031529 ruffle organization
GO:0031641 regulation of myelination
GO:0031667 response to nutrient levels
GO:0031669 cellular response to nutrient levels
GO:0031929 TOR signaling
GO:0031931 TORC1 complex
GO:0031932 TORC2 complex
GO:0031998 regulation of fatty acid beta-oxidation
GO:0032095 regulation of response to food
GO:0032868 response to insulin
GO:0032956 regulation of actin cytoskeleton organization
GO:0032991 protein-containing complex
GO:0034198 cellular response to amino acid starvation
GO:0035176 social behavior
GO:0035264 multicellular organism growth
GO:0038202 TORC1 signaling
GO:0042060 wound healing
GO:0042220 response to cocaine
GO:0042752 regulation of circadian rhythm
GO:0042802 identical protein binding
GO:0043022 ribosome binding
GO:0043025 neuronal cell body
GO:0043087 regulation of GTPase activity
GO:0043200 response to amino acid
GO:0043278 response to morphine
GO:0043610 regulation of carbohydrate utilization
GO:0045182 translation regulator activity
GO:0045335 phagocytic vesicle
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045670 regulation of osteoclast differentiation
GO:0045727 positive regulation of translation
GO:0045792 negative regulation of cell size
GO:0045859 regulation of protein kinase activity
GO:0045945 positive regulation of transcription by RNA polymerase III
GO:0046777 protein autophosphorylation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048255 mRNA stabilization
GO:0048511 rhythmic process
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0048738 cardiac muscle tissue development
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050769 positive regulation of neurogenesis
GO:0050882 voluntary musculoskeletal movement
GO:0051219 phosphoprotein binding
GO:0051496 positive regulation of stress fiber assembly
GO:0051549 positive regulation of keratinocyte migration
GO:0051647 nucleus localization
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0055006 cardiac cell development
GO:0055013 cardiac muscle cell development
GO:0060048 cardiac muscle contraction
GO:0060135 maternal process involved in female pregnancy
GO:0060252 positive regulation of glial cell proliferation
GO:0060999 positive regulation of dendritic spine development
GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071230 cellular response to amino acid stimulus
GO:0071233 cellular response to leucine
GO:0071456 cellular response to hypoxia
GO:0090335 regulation of brown fat cell differentiation
GO:0090559 regulation of membrane permeability
GO:0098978 glutamatergic synapse
GO:0099524 postsynaptic cytosol
GO:0099547 regulation of translation at synapse, modulating synaptic transmission
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901216 positive regulation of neuron death
GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO:1903691 positive regulation of wound healing, spreading of epidermal cells
GO:1904000 positive regulation of eating behavior
GO:1904056 positive regulation of cholangiocyte proliferation
GO:1904058 positive regulation of sensory perception of pain
GO:1904059 regulation of locomotor rhythm
GO:1904193 negative regulation of cholangiocyte apoptotic process
GO:1904197 positive regulation of granulosa cell proliferation
GO:1904206 positive regulation of skeletal muscle hypertrophy
GO:1904213 negative regulation of iodide transmembrane transport
GO:1990253 cellular response to leucine starvation

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Endoplasmic reticulum membrane
Golgi apparatus membrane
Lysosome
Lysosome membrane
Mitochondrion outer membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR003151 PIK-related kinase, FATDomainDomain
IPR003152 FATC domainDomainDomain
IPR009076 FKBP12-rapamycin binding domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011989 Armadillo-like helicalFamilyHomologous superfamily
IPR014009 PIK-related kinaseDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR024585 Domain of unknown function DUF3385, target of rapamycin proteinDomainDomain
IPR026683 Serine/threonine-protein kinase TORFamilyFamily
IPR036738 FKBP12-rapamycin binding domain superfamilyFamilyHomologous superfamily
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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