Entity Details

Primary name PNKP_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9JLV6
EntryNamePNKP_MOUSE
FullNameBifunctional polynucleotide phosphatase/kinase
TaxID10090
Evidenceevidence at protein level
Length522
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0003690 double-stranded DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0006281 DNA repair
GO:0006979 response to oxidative stress
GO:0010836 negative regulation of protein ADP-ribosylation
GO:0016311 dephosphorylation
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0042769 DNA damage response, detection of DNA damage
GO:0046403 polynucleotide 3'-phosphatase activity
GO:0046404 polydeoxyribonucleotide 5'-hydroxyl-kinase activity
GO:0046939 nucleotide phosphorylation
GO:0051973 positive regulation of telomerase activity
GO:1904355 positive regulation of telomere capping
GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR006549 HAD-superfamily hydrolase,subfamily IIIADomainDomain
IPR006550 Bifunctional polynucleotide phosphatase/kinase PNKPFamilyFamily
IPR006551 Polynucleotide 3'-phosphataseDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR013954 Polynucleotide kinase 3 phosphataseFamilyFamily
IPR023214 HAD superfamilyFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036412 HAD-like superfamilyFamilyHomologous superfamily
IPR041388 PNK, FHA domainDomainDomain

Diseases

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Interactions

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