Entity Details

Primary name HEY2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9QUS4
EntryNameHEY2_MOUSE
FullNameHairy/enhancer-of-split related with YRPW motif protein 2
TaxID10090
Evidenceevidence at protein level
Length339
SequenceStatuscomplete
DateCreated2006-07-11
DateModified2021-06-02

Ontological Relatives

GenesHey2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001568 blood vessel development
GO:0001570 vasculogenesis
GO:0003150 muscular septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003171 atrioventricular valve development
GO:0003180 aortic valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003186 tricuspid valve morphogenesis
GO:0003195 tricuspid valve formation
GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0003208 cardiac ventricle morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003300 cardiac muscle hypertrophy
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007219 Notch signaling pathway
GO:0007389 pattern specification process
GO:0008134 transcription factor binding
GO:0009948 anterior/posterior axis specification
GO:0009952 anterior/posterior pattern specification
GO:0010460 positive regulation of heart rate
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0014031 mesenchymal cell development
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0016580 Sin3 complex
GO:0017053 transcription repressor complex
GO:0035910 ascending aorta morphogenesis
GO:0035912 dorsal aorta morphogenesis
GO:0036304 umbilical cord morphogenesis
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0045165 cell fate commitment
GO:0045607 regulation of inner ear auditory receptor cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0050767 regulation of neurogenesis
GO:0055015 ventricular cardiac muscle cell development
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060347 heart trabecula formation
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter
GO:0060716 labyrinthine layer blood vessel development
GO:0060840 artery development
GO:0060842 arterial endothelial cell differentiation
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060977 coronary vasculature morphogenesis
GO:0061156 pulmonary artery morphogenesis
GO:0061314 Notch signaling involved in heart development
GO:0065004 protein-DNA complex assembly
GO:0070168 negative regulation of biomineral tissue development
GO:0072359 circulatory system development
GO:0090102 cochlea development
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000678 negative regulation of transcription regulatory region DNA binding
GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
GO:2001212 regulation of vasculogenesis

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003650 Orange domainDomainDomain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions