Entity Details

Primary name FAK2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9QVP9
EntryNameFAK2_MOUSE
FullNameProtein-tyrosine kinase 2-beta
TaxID10090
Evidenceevidence at protein level
Length1009
SequenceStatuscomplete
DateCreated2002-01-23
DateModified2021-06-02

Ontological Relatives

GenesPtk2b

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001525 angiogenesis
GO:0001556 oocyte maturation
GO:0001666 response to hypoxia
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002040 sprouting angiogenesis
GO:0002250 adaptive immune response
GO:0002315 marginal zone B cell differentiation
GO:0004672 protein kinase activity
GO:0004683 calmodulin-dependent protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004972 NMDA glutamate receptor activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0006468 protein phosphorylation
GO:0006968 cellular defense response
GO:0006970 response to osmotic stress
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007172 signal complex assembly
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007229 integrin-mediated signaling pathway
GO:0008022 protein C-terminus binding
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009612 response to mechanical stimulus
GO:0009725 response to hormone
GO:0009749 response to glucose
GO:0010226 response to lithium ion
GO:0010595 positive regulation of endothelial cell migration
GO:0010656 negative regulation of muscle cell apoptotic process
GO:0010752 regulation of cGMP-mediated signaling
GO:0010758 regulation of macrophage chemotaxis
GO:0010976 positive regulation of neuron projection development
GO:0014009 glial cell proliferation
GO:0014069 postsynaptic density
GO:0017146 NMDA selective glutamate receptor complex
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019899 enzyme binding
GO:0030027 lamellipodium
GO:0030154 cell differentiation
GO:0030155 regulation of cell adhesion
GO:0030279 negative regulation of ossification
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030502 negative regulation of bone mineralization
GO:0030838 positive regulation of actin filament polymerization
GO:0031175 neuron projection development
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031625 ubiquitin protein ligase binding
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032960 regulation of inositol trisphosphate biosynthetic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035902 response to immobilization stress
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042976 activation of Janus kinase activity
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043066 negative regulation of apoptotic process
GO:0043149 stress fiber assembly
GO:0043197 dendritic spine
GO:0043267 negative regulation of potassium ion transport
GO:0043423 3-phosphoinositide-dependent protein kinase binding
GO:0043507 positive regulation of JUN kinase activity
GO:0043524 negative regulation of neuron apoptotic process
GO:0043534 blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044297 cell body
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045453 bone resorption
GO:0045471 response to ethanol
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045727 positive regulation of translation
GO:0045766 positive regulation of angiogenesis
GO:0045860 positive regulation of protein kinase activity
GO:0046330 positive regulation of JNK cascade
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048041 focal adhesion assembly
GO:0048471 perinuclear region of cytoplasm
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050848 regulation of calcium-mediated signaling
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051591 response to cAMP
GO:0051592 response to calcium ion
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060291 long-term synaptic potentiation
GO:0060292 long-term synaptic depression
GO:0070098 chemokine-mediated signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071300 cellular response to retinoic acid
GO:0071498 cellular response to fluid shear stress
GO:0086100 endothelin receptor signaling pathway
GO:0090630 activation of GTPase activity
GO:0097440 apical dendrite
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:2000058 regulation of ubiquitin-dependent protein catabolic process
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2000114 regulation of establishment of cell polarity
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000310 regulation of NMDA receptor activity
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000538 positive regulation of B cell chemotaxis
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR005189 Focal adhesion kinase, targeting (FAT) domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR014352 FERM/acyl-CoA-binding protein superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR019748 FERM central domainDomainDomain
IPR019749 Band 4.1 domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR030610 Protein-tyrosine kinase 2-betaFamilyFamily
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR036137 Focal adhesion kinase, targeting (FAT) domain superfamilyFamilyHomologous superfamily
IPR041390 Focal adhesion kinase, N-terminalDomainDomain
IPR041784 FAK1/PYK2, FERM domain C-lobeDomainDomain

Diseases

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