Entity Details

Primary name HCN2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO88703
EntryNameHCN2_MOUSE
FullNamePotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
TaxID10090
Evidenceevidence at protein level
Length863
SequenceStatuscomplete
DateCreated2003-02-28
DateModified2021-06-02

Ontological Relatives

GenesHcn2

GO terms

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GOName
GO:0005222 intracellular cAMP-activated cation channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0030165 PDZ domain binding
GO:0030424 axon
GO:0030552 cAMP binding
GO:0032590 dendrite membrane
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0036477 somatodendritic compartment
GO:0042391 regulation of membrane potential
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
GO:0044877 protein-containing complex binding
GO:0045202 synapse
GO:0060090 molecular adaptor activity
GO:0071320 cellular response to cAMP
GO:0071321 cellular response to cGMP
GO:0071805 potassium ion transmembrane transport
GO:0098719 sodium ion import across plasma membrane
GO:0098855 HCN channel complex
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERGFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR013621 Ion transport N-terminalDomainDomain
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR018488 Cyclic nucleotide-binding, conserved siteSiteConserved site
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily

Diseases

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