Entity Details

Primary name HCN1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO88704
EntryNameHCN1_MOUSE
FullNamePotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
TaxID10090
Evidenceevidence at protein level
Length910
SequenceStatuscomplete
DateCreated2003-02-28
DateModified2021-06-02

Ontological Relatives

GenesHcn1

GO terms

Show/Hide Table
GOName
GO:0003254 regulation of membrane depolarization
GO:0005222 intracellular cAMP-activated cation channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008022 protein C-terminus binding
GO:0009986 cell surface
GO:0016323 basolateral plasma membrane
GO:0022843 voltage-gated cation channel activity
GO:0030424 axon
GO:0030425 dendrite
GO:0030552 cAMP binding
GO:0032590 dendrite membrane
GO:0035725 sodium ion transmembrane transport
GO:0036477 somatodendritic compartment
GO:0042391 regulation of membrane potential
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
GO:0043679 axon terminus
GO:0044877 protein-containing complex binding
GO:0045176 apical protein localization
GO:0045202 synapse
GO:0045759 negative regulation of action potential
GO:0046549 retinal cone cell development
GO:0051289 protein homotetramerization
GO:0051592 response to calcium ion
GO:0071320 cellular response to cAMP
GO:0071805 potassium ion transmembrane transport
GO:0097440 apical dendrite
GO:0098855 HCN channel complex
GO:1902630 regulation of membrane hyperpolarization
GO:2001259 positive regulation of cation channel activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000595 Cyclic nucleotide-binding domainDomainDomain
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERGFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR013621 Ion transport N-terminalDomainDomain
IPR014710 RmlC-like jelly roll foldFamilyHomologous superfamily
IPR018488 Cyclic nucleotide-binding, conserved siteSiteConserved site
IPR018490 Cyclic nucleotide-binding-likeFamilyHomologous superfamily
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily
IPR030169 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1FamilyFamily

Diseases

Show/Hide Table

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
HCN1_MOUSEHCN1_MOUSEIntAct22006928 details
HCN1_MOUSEPEX5R_MOUSEBioGRID, IntAct15564593 28671696 details
HCN1_MOUSEHCN2_MOUSEBioGRID, IntAct12928435 28671696 32325033 details