Entity Details

Primary name VAV3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9R0C8
EntryNameVAV3_MOUSE
FullNameGuanine nucleotide exchange factor VAV3
TaxID10090
Evidenceevidence at protein level
Length847
SequenceStatuscomplete
DateCreated2001-01-24
DateModified2021-06-02

Ontological Relatives

GenesVav3

GO terms

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GOName
GO:0001525 angiogenesis
GO:0001772 immunological synapse
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006906 vesicle fusion
GO:0006974 cellular response to DNA damage stimulus
GO:0007229 integrin-mediated signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0008361 regulation of cell size
GO:0016477 cell migration
GO:0030031 cell projection assembly
GO:0030032 lamellipodium assembly
GO:0030593 neutrophil chemotaxis
GO:0030890 positive regulation of B cell proliferation
GO:0042493 response to drug
GO:0043087 regulation of GTPase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045785 positive regulation of cell adhesion
GO:0046872 metal ion binding
GO:0050853 B cell receptor signaling pathway

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved siteSiteConserved site
IPR001452 SH3 domainDomainDomain
IPR001715 Calponin homology domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR003096 Smooth muscle protein/calponinFamilyFamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domainDomainDomain
IPR035734 VAV3 protein, second SH3 domainDomainDomain
IPR035881 VAV3, SH2 domainDomainDomain
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily
IPR037832 Vav, PH domainDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
VAV3_MOUSEITB3_MOUSEBioGRID30333137 details
VAV3_MOUSETRAF6_MOUSEBioGRID27507811 details