Entity Details

Primary name IKKE_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9R0T8
EntryNameIKKE_MOUSE
FullNameInhibitor of nuclear factor kappa-B kinase subunit epsilon
TaxID10090
Evidenceevidence at protein level
Length717
SequenceStatuscomplete
DateCreated2001-06-20
DateModified2021-06-02

Ontological Relatives

GenesIkbke

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004704 NF-kappaB-inducing kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0006955 immune response
GO:0008384 IkappaB kinase activity
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010467 gene expression
GO:0010884 positive regulation of lipid storage
GO:0016605 PML body
GO:0018105 peptidyl-serine phosphorylation
GO:0031625 ubiquitin protein ligase binding
GO:0031966 mitochondrial membrane
GO:0034340 response to type I interferon
GO:0035456 response to interferon-beta
GO:0036435 K48-linked polyubiquitin modification-dependent protein binding
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254 regulation of protein-containing complex assembly
GO:0048255 mRNA stabilization
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0097400 interleukin-17-mediated signaling pathway
GO:0098586 cellular response to virus

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR041087 TANK binding kinase 1, ubiquitin-like domainDomainDomain
IPR041309 TANK-binding kinase 1, coiled-coil domain 1DomainDomain

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
IKKE_MOUSECIKS_MOUSEBioGRID, InnateDB21822257 22851696 details
IKKE_MOUSEUBC_MOUSEBioGRID24882218 details
IKKE_MOUSETNFA_MOUSEBioGRID30420664 details