Entity Details

Primary name FOXO1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9R1E0
EntryNameFOXO1_MOUSE
FullNameForkhead box protein O1
TaxID10090
Evidenceevidence at protein level
Length652
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesFoxo1

GO terms

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GOName
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 transcription coactivator binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001568 blood vessel development
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006111 regulation of gluconeogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006914 autophagy
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008286 insulin receptor signaling pathway
GO:0009267 cellular response to starvation
GO:0010508 positive regulation of autophagy
GO:0030154 cell differentiation
GO:0031625 ubiquitin protein ligase binding
GO:0032869 cellular response to insulin stimulus
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0034599 cellular response to oxidative stress
GO:0042127 regulation of cell population proliferation
GO:0042593 glucose homeostasis
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045599 negative regulation of fat cell differentiation
GO:0045722 positive regulation of gluconeogenesis
GO:0045732 positive regulation of protein catabolic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051721 protein phosphatase 2A binding
GO:0070166 enamel mineralization
GO:0070301 cellular response to hydrogen peroxide
GO:0070542 response to fatty acid
GO:0071455 cellular response to hyperoxia
GO:0071549 cellular response to dexamethasone stimulus
GO:0071732 cellular response to nitric oxide
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097150 neuronal stem cell population maintenance
GO:1902617 response to fluoride
GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress
GO:1990841 promoter-specific chromatin binding
GO:2000177 regulation of neural precursor cell proliferation
GO:2000377 regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR032067 FOXO protein, transactivation domainDomainDomain
IPR032068 FOXO protein, KIX-binding domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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