Entity Details

Primary name HIC1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9R1Y5
EntryNameHIC1_MOUSE
FullNameHypermethylated in cancer 1 protein
TaxID10090
Evidenceevidence at protein level
Length733
SequenceStatuscomplete
DateCreated2002-05-02
DateModified2021-06-02

Ontological Relatives

GenesHic1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007275 multicellular organism development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0042826 histone deacetylase binding
GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000210 BTB/POZ domainDomainDomain
IPR011333 SKP1/BTB/POZ domain superfamilyFamilyHomologous superfamily
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR028424 Hypermethylated in cancer 1 proteinFamilyFamily
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
HIC1_MOUSETF7L2_MOUSEBioGRID, MINT16724116 details
HIC1_MOUSESIR1_MOUSEUniProt16269335 details
HIC1_MOUSESIR1_HUMANUniProt17283066 details