Entity Details

Primary name SCN8A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9WTU3
EntryNameSCN8A_MOUSE
FullNameSodium channel protein type 8 subunit alpha
TaxID10090
Evidenceevidence at protein level
Length1978
SequenceStatuscomplete
DateCreated2003-08-15
DateModified2021-06-02

Ontological Relatives

GenesScn8a

GO terms

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GOName
GO:0001518 voltage-gated sodium channel complex
GO:0005244 voltage-gated ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0006814 sodium ion transport
GO:0007517 muscle organ development
GO:0007605 sensory perception of sound
GO:0007626 locomotory behavior
GO:0007628 adult walking behavior
GO:0008344 adult locomotory behavior
GO:0009636 response to toxic substance
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019228 neuronal action potential
GO:0030018 Z disc
GO:0030054 cell junction
GO:0030424 axon
GO:0030425 dendrite
GO:0031402 sodium ion binding
GO:0033268 node of Ranvier
GO:0034706 sodium channel complex
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0043025 neuronal cell body
GO:0043194 axon initial segment
GO:0050905 neuromuscular process
GO:0086010 membrane depolarization during action potential
GO:0098688 parallel fiber to Purkinje cell synapse
GO:0098978 glutamatergic synapse
GO:0099059 integral component of presynaptic active zone membrane
GO:0099061 integral component of postsynaptic density membrane

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000048 IQ motif, EF-hand binding siteSiteBinding site
IPR001696 Voltage gated sodium channel, alpha subunitFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR008054 Voltage gated sodium channel, alpha-8 subunitFamilyFamily
IPR010526 Sodium ion transport-associatedDomainDomain
IPR024583 Voltage-gated Na+ ion channel, cytoplasmic domainDomainDomain
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily
IPR043203 Voltage-gated cation channel calcium and sodiumFamilyFamily
IPR044564 Voltage-gated sodium channel alpha subunit, inactivation gateDomainDomain

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
SCN8A_MOUSEMAP1B_MOUSEUniProt22474336 details
SCN8A_MOUSENEDD4_MOUSEBioGRID15123669 details