Entity Details

Primary name CHIP_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9WUD1
EntryNameCHIP_MOUSE
FullNameE3 ubiquitin-protein ligase CHIP
TaxID10090
Evidenceevidence at protein level
Length304
SequenceStatuscomplete
DateCreated2005-10-25
DateModified2021-06-02

Ontological Relatives

GenesStub1

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0001664 G protein-coupled receptor binding
GO:0002931 response to ischemia
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006457 protein folding
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0016567 protein ubiquitination
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0030018 Z disc
GO:0030433 ubiquitin-dependent ERAD pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030544 Hsp70 protein binding
GO:0030579 ubiquitin-dependent SMAD protein catabolic process
GO:0030674 protein-macromolecule adaptor activity
GO:0030911 TPR domain binding
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031072 heat shock protein binding
GO:0031371 ubiquitin conjugating enzyme complex
GO:0031398 positive regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0031647 regulation of protein stability
GO:0031943 regulation of glucocorticoid metabolic process
GO:0032091 negative regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034450 ubiquitin-ubiquitin ligase activity
GO:0034605 cellular response to heat
GO:0042405 nuclear inclusion body
GO:0042803 protein homodimerization activity
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045862 positive regulation of proteolysis
GO:0046332 SMAD binding
GO:0051087 chaperone binding
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0051604 protein maturation
GO:0051787 misfolded protein binding
GO:0051865 protein autoubiquitination
GO:0051879 Hsp90 protein binding
GO:0061630 ubiquitin protein ligase activity
GO:0061684 chaperone-mediated autophagy
GO:0070534 protein K63-linked ubiquitination
GO:0071218 cellular response to misfolded protein
GO:0071456 cellular response to hypoxia
GO:0090035 positive regulation of chaperone-mediated protein complex assembly
GO:0101031 chaperone complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR003613 U box domainDomainDomain
IPR011990 Tetratricopeptide-like helical domain superfamilyFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR019734 Tetratricopeptide repeatRepeatRepeat
IPR041312 CHIP, N-terminal tetratricopeptide repeat domainDomainDomain

Diseases

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Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
CHIP_MOUSEPKHO1_HUMANBioGRID, IntAct20368287 details
CHIP_MOUSEM3K2_HUMANBioGRID, MINT20588253 details
CHIP_MOUSEHS90A_HUMANBioGRID, UniProt15189447 16307917 details
CHIP_MOUSEUBE2N_HUMANBioGRID, UniProt16307917 details
CHIP_MOUSEILK_MOUSEBioGRID, MINT23612611 28546219 details
CHIP_MOUSEA4_MOUSEBioGRID17317785 27325702 details
CHIP_MOUSEDAAF4_HUMANBioGRID15189447 details
CHIP_MOUSEDAAF4_MOUSEBioGRID15189447 19737534 details
CHIP_MOUSEUB2D1_HUMANBioGRID23612611 31951392 details
CHIP_MOUSECHIP_MOUSEBioGRID11435423 16307917 26206088 31951392 details
CHIP_MOUSEUB2D3_HUMANBioGRID11435423 details
CHIP_MOUSECDK5_MOUSEBioGRID26206088 details
CHIP_MOUSEUBX2A_MOUSEBioGRID26265139 30107089 details
CHIP_MOUSEOTUD4_HUMANBioGRID31138677 details
CHIP_MOUSEUBP21_HUMANBioGRID31951392 details
CHIP_MOUSETAU_HUMANBioGRID31951392 details
CHIP_MOUSEM3K2_MOUSEMINT20588253 details
CHIP_MOUSE2AAA_MOUSEBioGRID, MINT19818709 32325033 details
CHIP_MOUSEAKT1_MOUSEBioGRID, DIP18292230 details
CHIP_MOUSELRRK2_HUMANDIP19196961 details
CHIP_MOUSELRRK2_MOUSEBioGRID, DIP19196961 details
CHIP_MOUSETAU_MOUSEBioGRID14962978 32325033 details
CHIP_MOUSEHSP74_HUMANBioGRID15189447 details
CHIP_MOUSEATX3_MOUSEBioGRID15664989 details
CHIP_MOUSETFE2_MOUSEBioGRID15456869 details
CHIP_MOUSECUL1_HUMANBioGRID15456869 details
CHIP_MOUSESKP2_HUMANBioGRID15456869 details
CHIP_MOUSESODC_HUMANBioGRID15198682 details
CHIP_MOUSEHSP7C_MOUSEBioGRID23612611 32325033 details
CHIP_MOUSEHS90B_MOUSEBioGRID23612611 details
CHIP_MOUSEFOXP3_MOUSEBioGRID23973223 details
CHIP_MOUSEHYOU1_MOUSEBioGRID24218449 details
CHIP_MOUSES61A1_MOUSEBioGRID24218449 details
CHIP_MOUSEIL4RA_MOUSEBioGRID24251647 details
CHIP_MOUSEHS71B_MOUSEBioGRID24251647 details
CHIP_MOUSETRAF6_MOUSEBioGRID24578159 details
CHIP_MOUSESP7_MOUSEBioGRID25818514 details
CHIP_MOUSEM3K14_MOUSEBioGRID25792747 details
CHIP_MOUSETRAF3_MOUSEBioGRID25792747 details
CHIP_MOUSEACHA3_MOUSEBioGRID26265139 details
CHIP_MOUSEAQP2_MOUSEBioGRID29145196 details
CHIP_MOUSEGRP75_MOUSEBioGRID30107089 details