Entity Details

Primary name TBK1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9WUN2
EntryNameTBK1_MOUSE
FullNameSerine/threonine-protein kinase TBK1
TaxID10090
Evidenceevidence at protein level
Length729
SequenceStatuscomplete
DateCreated2005-12-20
DateModified2021-06-02

Ontological Relatives

GenesTbk1

GO terms

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GOName
GO:0002218 activation of innate immune response
GO:0003676 nucleic acid binding
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0010468 regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016239 positive regulation of macroautophagy
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019903 protein phosphatase binding
GO:0031323 regulation of cellular metabolic process
GO:0032479 regulation of type I interferon production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0042802 identical protein binding
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043231 intracellular membrane-bounded organelle
GO:0044565 dendritic cell proliferation
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050830 defense response to Gram-positive bacterium
GO:0051219 phosphoprotein binding
GO:0051607 defense response to virus
GO:0060340 positive regulation of type I interferon-mediated signaling pathway
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1904417 positive regulation of xenophagy

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR041087 TANK binding kinase 1, ubiquitin-like domainDomainDomain
IPR041309 TANK-binding kinase 1, coiled-coil domain 1DomainDomain

Diseases

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