Entity Details

Primary name GSK3B_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9WV60
EntryNameGSK3B_MOUSE
FullNameGlycogen synthase kinase-3 beta
TaxID10090
Evidenceevidence at protein level
Length420
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesGsk3b

GO terms

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GOName
GO:0000320 re-entry into mitotic cell cycle
GO:0001558 regulation of cell growth
GO:0001837 epithelial to mesenchymal transition
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002020 protease binding
GO:0002039 p53 binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005977 glycogen metabolic process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006468 protein phosphorylation
GO:0006611 protein export from nucleus
GO:0006983 ER overload response
GO:0007010 cytoskeleton organization
GO:0007163 establishment or maintenance of cell polarity
GO:0007165 signal transduction
GO:0007409 axonogenesis
GO:0007520 myoblast fusion
GO:0007623 circadian rhythm
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008286 insulin receptor signaling pathway
GO:0009887 animal organ morphogenesis
GO:0010043 response to zinc ion
GO:0010508 positive regulation of autophagy
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010822 positive regulation of mitochondrion organization
GO:0010918 positive regulation of mitochondrial membrane potential
GO:0010975 regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0014043 negative regulation of neuron maturation
GO:0014069 postsynaptic density
GO:0014902 myotube differentiation
GO:0016020 membrane
GO:0016055 Wnt signaling pathway
GO:0016301 kinase activity
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019901 protein kinase binding
GO:0021766 hippocampus development
GO:0030010 establishment of cell polarity
GO:0030011 maintenance of cell polarity
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0030516 regulation of axon extension
GO:0030877 beta-catenin destruction complex
GO:0031175 neuron projection development
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031334 positive regulation of protein-containing complex assembly
GO:0031625 ubiquitin protein ligase binding
GO:0032007 negative regulation of TOR signaling
GO:0032091 negative regulation of protein binding
GO:0032092 positive regulation of protein binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032886 regulation of microtubule-based process
GO:0032991 protein-containing complex
GO:0033690 positive regulation of osteoblast proliferation
GO:0034236 protein kinase A catalytic subunit binding
GO:0034392 negative regulation of smooth muscle cell apoptotic process
GO:0034452 dynactin binding
GO:0035255 ionotropic glutamate receptor binding
GO:0035372 protein localization to microtubule
GO:0035556 intracellular signal transduction
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0035733 hepatic stellate cell activation
GO:0036016 cellular response to interleukin-3
GO:0042752 regulation of circadian rhythm
GO:0042981 regulation of apoptotic process
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043197 dendritic spine
GO:0043198 dendritic shaft
GO:0043227 membrane-bounded organelle
GO:0043407 negative regulation of MAP kinase activity
GO:0043525 positive regulation of neuron apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0044027 hypermethylation of CpG island
GO:0044297 cell body
GO:0045121 membrane raft
GO:0045444 fat cell differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045773 positive regulation of axon extension
GO:0045886 negative regulation of synaptic assembly at neuromuscular junction
GO:0045887 positive regulation of synaptic assembly at neuromuscular junction
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046777 protein autophosphorylation
GO:0046827 positive regulation of protein export from nucleus
GO:0046849 bone remodeling
GO:0048156 tau protein binding
GO:0048168 regulation of neuronal synaptic plasticity
GO:0048471 perinuclear region of cytoplasm
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048814 regulation of dendrite morphogenesis
GO:0050321 tau-protein kinase activity
GO:0050770 regulation of axonogenesis
GO:0050774 negative regulation of dendrite morphogenesis
GO:0051001 negative regulation of nitric-oxide synthase activity
GO:0051059 NF-kappaB binding
GO:0060070 canonical Wnt signaling pathway
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0070840 dynein complex binding
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0071109 superior temporal gyrus development
GO:0071260 cellular response to mechanical stimulus
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090290 positive regulation of osteoclast proliferation
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097284 hepatocyte apoptotic process
GO:0098685 Schaffer collateral - CA1 synapse
GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:0098978 glutamatergic synapse
GO:0099159 regulation of modification of postsynaptic structure
GO:0106027 neuron projection organization
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0150101 regulation of microtubule anchoring at centrosome
GO:1900181 negative regulation of protein localization to nucleus
GO:1900271 regulation of long-term synaptic potentiation
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901215 negative regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901984 negative regulation of protein acetylation
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1904339 negative regulation of dopaminergic neuron differentiation
GO:1904646 cellular response to amyloid-beta
GO:1904780 negative regulation of protein localization to centrosome
GO:1904781 positive regulation of protein localization to centrosome
GO:1990904 ribonucleoprotein complex
GO:1990909 Wnt signalosome
GO:2000171 negative regulation of dendrite development
GO:2000300 regulation of synaptic vesicle exocytosis
GO:2000463 positive regulation of excitatory postsynaptic potential
GO:2000573 positive regulation of DNA biosynthetic process
GO:2000727 positive regulation of cardiac muscle cell differentiation
GO:2000738 positive regulation of stem cell differentiation
GO:2001223 negative regulation of neuron migration

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033573 Glycogen synthase kinase-3 betaFamilyFamily
IPR039192 Glycogen synthase kinase 3, catalytic domainDomainDomain

Diseases

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Interactions

44 interactions

InteractorPartnerSourcesPublicationsLink
GSK3B_MOUSEAXIN1_MOUSEbhf-ucl, BioGRID, MINT10318824 14734535 18316368 19107203 19581931 21242974 22682247 25331900 details
GSK3B_MOUSEBHE40_HUMANIntAct23555304 details
GSK3B_MOUSEBHE41_MOUSEIntAct23555304 details
GSK3B_MOUSECSK2B_HUMANIntAct23555304 details
GSK3B_MOUSEFBW1A_MOUSEIntAct23555304 details
GSK3B_MOUSELRP6_HUMANbhf-ucl19107203 details
GSK3B_MOUSECTNB1_MOUSEbhf-ucl, BioGRID10318824 12874278 15327768 19107203 32325033 details
GSK3B_MOUSEAXIN2_MOUSEBioGRID9554852 details
GSK3B_MOUSECTND1_MOUSEBioGRID19706605 details
GSK3B_MOUSENF2L2_MOUSEBioGRID21245377 details
GSK3B_MOUSECSN8_MOUSEBioGRID19576224 details
GSK3B_MOUSEAKT1_MOUSEBioGRID18851840 20576936 21084607 32325033 details
GSK3B_MOUSEARRB2_MOUSEBioGRID16051150 details
GSK3B_MOUSEAKT2_MOUSEBioGRID20576936 details
GSK3B_MOUSEMCL1_MOUSEBioGRID22976837 details
GSK3B_MOUSECEBPB_MOUSEBioGRID11278638 details
GSK3B_MOUSETAU_MOUSEBioGRID23362255 30068389 details
GSK3B_MOUSEEPM2A_MOUSEIntAct16959610 details
GSK3B_MOUSEDISC1_MOUSEIntAct19303846 details
GSK3B_MOUSEMACF1_MOUSEIntAct21295697 details
GSK3B_MOUSELRP6_MOUSEMINT22491013 details
GSK3B_MOUSEDACT2_MOUSEUniProt21718540 details
GSK3B_MOUSEDACT1_MOUSEUniProt21718540 details
GSK3B_MOUSEKAPCA_MOUSEbhf-ucl11035810 details
GSK3B_MOUSEAPC_MOUSEbhf-ucl8638126 details
GSK3B_MOUSEDZIP1_MOUSEDIP25860027 details
GSK3B_MOUSEE2F1_MOUSEBioGRID18367454 details
GSK3B_MOUSESMAD3_MOUSEBioGRID18172167 details
GSK3B_MOUSEKPCZ_MOUSEBioGRID16510873 17053159 details
GSK3B_MOUSECTND2_MOUSEBioGRID20623542 details
GSK3B_MOUSECSN2_MOUSEBioGRID19576224 details
GSK3B_MOUSEMDM2_MOUSEBioGRID21738215 details
GSK3B_MOUSEP53_MOUSEBioGRID21738215 details
GSK3B_MOUSENEMO_MOUSEBioGRID12808104 details
GSK3B_MOUSEPKHO1_MOUSEBioGRID24777252 details
GSK3B_MOUSEM3K4_MOUSEBioGRID17726008 details
GSK3B_MOUSETLR3_MOUSEBioGRID25828701 details
GSK3B_MOUSETRAF6_MOUSEBioGRID25828701 details
GSK3B_MOUSEM3K7_MOUSEBioGRID25828701 details
GSK3B_MOUSETAB1_MOUSEBioGRID25828701 details
GSK3B_MOUSETAB2_MOUSEBioGRID25828701 details
GSK3B_MOUSETCAM2_MOUSEBioGRID25828701 details
GSK3B_MOUSESNAI1_MOUSEBioGRID28892081 details
GSK3B_MOUSECD5R1_MOUSEBioGRID25331900 details