Entity Details

Primary name FOXO3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9WVH4
EntryNameFOXO3_MOUSE
FullNameForkhead box protein O3
TaxID10090
Evidenceevidence at protein level
Length672
SequenceStatuscomplete
DateCreated2012-01-25
DateModified2021-06-02

Ontological Relatives

GenesFoxo3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001221 transcription coregulator binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001542 ovulation from ovarian follicle
GO:0001544 initiation of primordial ovarian follicle growth
GO:0001547 antral ovarian follicle growth
GO:0001556 oocyte maturation
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006390 mitochondrial transcription
GO:0006417 regulation of translation
GO:0007568 aging
GO:0008013 beta-catenin binding
GO:0010508 positive regulation of autophagy
GO:0014737 positive regulation of muscle atrophy
GO:0016020 membrane
GO:0019901 protein kinase binding
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0030336 negative regulation of cell migration
GO:0031490 chromatin DNA binding
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034246 mitochondrial transcription factor activity
GO:0034599 cellular response to oxidative stress
GO:0042149 cellular response to glucose starvation
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042594 response to starvation
GO:0043065 positive regulation of apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048854 brain morphogenesis
GO:0070542 response to fatty acid
GO:0071333 cellular response to glucose stimulus
GO:0071386 cellular response to corticosterone stimulus
GO:0071456 cellular response to hypoxia
GO:0071548 response to dexamethasone
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097150 neuronal stem cell population maintenance
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1904646 cellular response to amyloid-beta
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990785 response to water-immersion restraint stress
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000177 regulation of neural precursor cell proliferation
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2000377 regulation of reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion matrix
Mitochondrion outer membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR032067 FOXO protein, transactivation domainDomainDomain
IPR032068 FOXO protein, KIX-binding domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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