Entity Details

Primary name APAF_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO88879
EntryNameAPAF_MOUSE
FullNameApoptotic protease-activating factor 1
TaxID10090
Evidenceevidence at protein level
Length1249
SequenceStatuscomplete
DateCreated2002-01-23
DateModified2021-06-02

Ontological Relatives

GenesApaf1

GO terms

Show/Hide Table
GOName
GO:0001666 response to hypoxia
GO:0001822 kidney development
GO:0001843 neural tube closure
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007275 multicellular organism development
GO:0007420 brain development
GO:0007568 aging
GO:0007584 response to nutrient
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010659 cardiac muscle cell apoptotic process
GO:0030154 cell differentiation
GO:0030900 forebrain development
GO:0031072 heat shock protein binding
GO:0032991 protein-containing complex
GO:0042802 identical protein binding
GO:0043293 apoptosome
GO:0043531 ADP binding
GO:0051402 neuron apoptotic process
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:1902510 regulation of apoptotic DNA fragmentation
GO:2001235 positive regulation of apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR001680 WD40 repeatRepeatRepeat
IPR002182 NB-ARCDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR017251 Apoptotic protease-activating factor 1FamilyFamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR020472 G-protein beta WD-40 repeatRepeatRepeat
IPR024977 Anaphase-promoting complex subunit 4, WD40 domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR037963 Apoptotic Protease-Activating Factor 1, CARD domainDomainDomain
IPR041452 APAF-1 helical domainDomainDomain

Diseases

Show/Hide Table

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
APAF_MOUSEPP1A_MOUSEBioGRID, IntAct17274640 details