Entity Details

Primary name LHX2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9Z0S2
EntryNameLHX2_MOUSE
FullNameLIM/homeobox protein Lhx2
TaxID10090
Evidenceevidence at protein level
Length406
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesLhx2

GO terms

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GOName
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001843 neural tube closure
GO:0001942 hair follicle development
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007498 mesoderm development
GO:0008134 transcription factor binding
GO:0009953 dorsal/ventral pattern formation
GO:0021537 telencephalon development
GO:0021772 olfactory bulb development
GO:0021978 telencephalon regionalization
GO:0021987 cerebral cortex development
GO:0022008 neurogenesis
GO:0030182 neuron differentiation
GO:0043565 sequence-specific DNA binding
GO:0045199 maintenance of epithelial cell apical/basal polarity
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048675 axon extension
GO:0050768 negative regulation of neurogenesis
GO:0060041 retina development in camera-type eye
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000678 negative regulation of transcription regulatory region DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR001781 Zinc finger, LIM-typeDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

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Interactions

6 interactions

InteractorPartnerSourcesPublicationsLink
LHX2_MOUSELDB2_MOUSEBioGRID, IntAct20211142 details
LHX2_MOUSELDB1_MOUSEBioGRID, IntAct20211142 details
LHX2_MOUSEMRTFA_MOUSEBioGRID, IntAct20211142 details
LHX2_MOUSEGMEB2_MOUSEBioGRID, IntAct20211142 details
LHX2_MOUSESSBP2_MOUSEBioGRID, IntAct20211142 details
LHX2_MOUSESSBP3_MOUSEBioGRID, IntAct20211142 details