Entity Details

Primary name AIFM1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9Z0X1
EntryNameAIFM1_MOUSE
FullNameApoptosis-inducing factor 1, mitochondrial
TaxID10090
Evidenceevidence at protein level
Length612
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesAifm1

GO terms

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GOName
GO:0002931 response to ischemia
GO:0003677 DNA binding
GO:0003954 NADH dehydrogenase activity
GO:0004174 electron-transferring-flavoprotein dehydrogenase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006979 response to oxidative stress
GO:0008637 apoptotic mitochondrial changes
GO:0009636 response to toxic substance
GO:0010942 positive regulation of cell death
GO:0016174 NAD(P)H oxidase H2O2-forming activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0030182 neuron differentiation
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0033108 mitochondrial respiratory chain complex assembly
GO:0043065 positive regulation of apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0045041 protein import into mitochondrial intermembrane space
GO:0046983 protein dimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0051402 neuron apoptotic process
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070301 cellular response to hydrogen peroxide
GO:0071392 cellular response to estradiol stimulus
GO:0071732 cellular response to nitric oxide
GO:0071949 FAD binding
GO:0090650 cellular response to oxygen-glucose deprivation
GO:1902065 response to L-glutamate
GO:1902510 regulation of apoptotic DNA fragmentation
GO:1904045 cellular response to aldosterone

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Mitochondrion inner membrane
Mitochondrion intermembrane space
Nucleus

Domains

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DomainNameCategoryType
IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamilyFamilyHomologous superfamily
IPR023753 FAD/NAD(P)-binding domainDomainDomain
IPR029324 Mitochondrial apoptosis-inducing factor, C-terminal domainDomainDomain
IPR036188 FAD/NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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