Entity Details

Primary name P63_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO88898
EntryNameP63_MOUSE
FullNameTumor protein 63
TaxID10090
Evidenceevidence at protein level
Length680
SequenceStatuscomplete
DateCreated2005-01-04
DateModified2021-06-02

Ontological Relatives

GenesTrp63

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001501 skeletal system development
GO:0001736 establishment of planar polarity
GO:0001738 morphogenesis of a polarized epithelium
GO:0001942 hair follicle development
GO:0002039 p53 binding
GO:0002064 epithelial cell development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0006338 chromatin remodeling
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0007389 pattern specification process
GO:0007499 ectoderm and mesoderm interaction
GO:0007569 cell aging
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0008544 epidermis development
GO:0009887 animal organ morphogenesis
GO:0009913 epidermal cell differentiation
GO:0009954 proximal/distal pattern formation
GO:0010259 multicellular organism aging
GO:0010481 epidermal cell division
GO:0010482 regulation of epidermal cell division
GO:0010838 positive regulation of keratinocyte proliferation
GO:0019904 protein domain specific binding
GO:0030154 cell differentiation
GO:0030216 keratinocyte differentiation
GO:0030326 embryonic limb morphogenesis
GO:0030425 dendrite
GO:0030850 prostate gland development
GO:0030855 epithelial cell differentiation
GO:0030859 polarized epithelial cell differentiation
GO:0031069 hair follicle morphogenesis
GO:0032991 protein-containing complex
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0036342 post-anal tail morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0043589 skin morphogenesis
GO:0043616 keratinocyte proliferation
GO:0045617 negative regulation of keratinocyte differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045747 positive regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048485 sympathetic nervous system development
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048807 female genitalia morphogenesis
GO:0050699 WW domain binding
GO:0051262 protein tetramerization
GO:0051402 neuron apoptotic process
GO:0060197 cloacal septation
GO:0060513 prostatic bud formation
GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0061436 establishment of skin barrier
GO:0097371 MDM2/MDM4 family protein binding
GO:0098773 skin epidermis development
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:1904674 positive regulation of somatic stem cell population maintenance
GO:1904888 cranial skeletal system development
GO:2000271 positive regulation of fibroblast apoptotic process
GO:2000381 negative regulation of mesoderm development
GO:2000773 negative regulation of cellular senescence
GO:2001235 positive regulation of apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001660 Sterile alpha motif domainDomainDomain
IPR002117 p53 tumour suppressor familyFamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR010991 p53, tetramerisation domainDomainDomain
IPR011615 p53, DNA-binding domainDomainDomain
IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR032645 Tumour protein p63FamilyFamily
IPR036674 p53-like tetramerisation domain superfamilyFamilyHomologous superfamily
IPR037611 Tumour protein p63, SAM domainDomainDomain

Diseases

Show/Hide Table