Entity Details

Primary name GRP1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9Z1S3
EntryNameGRP1_MOUSE
FullNameRAS guanyl-releasing protein 1
TaxID10090
Evidenceevidence at protein level
Length795
SequenceStatuscomplete
DateCreated2008-02-05
DateModified2021-06-02

Ontological Relatives

GenesRasgrp1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001934 positive regulation of protein phosphorylation
GO:0002437 inflammatory response to antigenic stimulus
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007264 small GTPase mediated signal transduction
GO:0008270 zinc ion binding
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0019992 diacylglycerol binding
GO:0030101 natural killer cell activation
GO:0030154 cell differentiation
GO:0031210 phosphatidylcholine binding
GO:0032252 secretory granule localization
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032816 positive regulation of natural killer cell activation
GO:0032825 positive regulation of natural killer cell differentiation
GO:0033089 positive regulation of T cell differentiation in thymus
GO:0042098 T cell proliferation
GO:0042100 B cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042802 identical protein binding
GO:0043303 mast cell degranulation
GO:0043406 positive regulation of MAP kinase activity
GO:0043547 positive regulation of GTPase activity
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0046330 positive regulation of JNK cascade
GO:0046579 positive regulation of Ras protein signal transduction
GO:0047496 vesicle transport along microtubule
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090630 activation of GTPase activity

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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