Entity Details

Primary name NFAC1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO88942
EntryNameNFAC1_MOUSE
FullNameNuclear factor of activated T-cells, cytoplasmic 1
TaxID10090
Evidenceevidence at protein level
Length717
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001837 epithelial to mesenchymal transition
GO:0001946 lymphangiogenesis
GO:0002337 B-1a B cell differentiation
GO:0003170 heart valve development
GO:0003176 aortic valve development
GO:0003177 pulmonary valve development
GO:0003179 heart valve morphogenesis
GO:0003180 aortic valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006816 calcium ion transport
GO:0007507 heart development
GO:0008134 transcription factor binding
GO:0010628 positive regulation of gene expression
GO:0014883 transition between fast and slow fiber
GO:0016604 nuclear body
GO:0030316 osteoclast differentiation
GO:0033173 calcineurin-NFAT signaling cascade
GO:0035556 intracellular signal transduction
GO:0042634 regulation of hair cycle
GO:0043565 sequence-specific DNA binding
GO:0045668 negative regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048273 mitogen-activated protein kinase p38 binding
GO:0060412 ventricular septum morphogenesis
GO:0060854 branching involved in lymph vessel morphogenesis
GO:0061384 heart trabecula morphogenesis
GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation
GO:1905314 semi-lunar valve development
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000647 negative regulation of stem cell proliferation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002909 IPT domainDomainDomain
IPR008366 Nuclear factor of activated T cells (NFAT)FamilyFamily
IPR008967 p53-like transcription factor, DNA-bindingFamilyHomologous superfamily
IPR011539 Rel homology domain (RHD), DNA-binding domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR015647 Nuclear factor of activated T-cells 1FamilyFamily
IPR032397 Rel homology dimerisation domainDomainDomain
IPR037059 Rel homology domain (RHD), DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
NFAC1_MOUSEPP2BA_HUMANMINT9660947 details