Entity Details

Primary name CHK2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9Z265
EntryNameCHK2_MOUSE
FullNameSerine/threonine-protein kinase Chk2
TaxID10090
Evidenceevidence at protein level
Length546
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesChek2

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000781 chromosome, telomeric region
GO:0001934 positive regulation of protein phosphorylation
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0006302 double-strand break repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010332 response to gamma radiation
GO:0016301 kinase activity
GO:0016605 PML body
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0035690 cellular response to drug
GO:0042176 regulation of protein catabolic process
GO:0042770 signal transduction in response to DNA damage
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044257 cellular protein catabolic process
GO:0044773 mitotic DNA damage checkpoint signaling
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0050821 protein stabilization
GO:0051301 cell division
GO:0071480 cellular response to gamma radiation
GO:0090307 mitotic spindle assembly
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903416 response to glycoside
GO:1903926 cellular response to bisphenol A
GO:2000002 negative regulation of DNA damage checkpoint
GO:2000210 positive regulation of anoikis

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000253 Forkhead-associated (FHA) domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
CHK2_MOUSEZN363_MOUSEBioGRID23449389 details