Entity Details

Primary name E2AK3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9Z2B5
EntryNameE2AK3_MOUSE
FullNameEukaryotic translation initiation factor 2-alpha kinase 3
TaxID10090
Evidenceevidence at protein level
Length1114
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesEif2ak3

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0002063 chondrocyte development
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006412 translation
GO:0006468 protein phosphorylation
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006983 ER overload response
GO:0007029 endoplasmic reticulum organization
GO:0007595 lactation
GO:0009967 positive regulation of signal transduction
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation
GO:0016021 integral component of membrane
GO:0017148 negative regulation of translation
GO:0018105 peptidyl-serine phosphorylation
GO:0019217 regulation of fatty acid metabolic process
GO:0019722 calcium-mediated signaling
GO:0019899 enzyme binding
GO:0019903 protein phosphatase binding
GO:0030282 bone mineralization
GO:0030433 ubiquitin-dependent ERAD pathway
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031016 pancreas development
GO:0031018 endocrine pancreas development
GO:0031642 negative regulation of myelination
GO:0032055 negative regulation of translation in response to stress
GO:0032092 positive regulation of protein binding
GO:0032933 SREBP signaling pathway
GO:0034198 cellular response to amino acid starvation
GO:0034976 response to endoplasmic reticulum stress
GO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress
GO:0036499 PERK-mediated unfolded protein response
GO:0042149 cellular response to glucose starvation
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0044322 endoplasmic reticulum quality control compartment
GO:0045444 fat cell differentiation
GO:0045943 positive regulation of transcription by RNA polymerase I
GO:0046777 protein autophosphorylation
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0051879 Hsp90 protein binding
GO:0060734 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070417 cellular response to cold
GO:0071074 eukaryotic initiation factor eIF2 binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900182 positive regulation of protein localization to nucleus
GO:1902010 negative regulation of translation in response to endoplasmic reticulum stress
GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1903788 positive regulation of glutathione biosynthetic process
GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011047 Quinoprotein alcohol dehydrogenase-like superfamilyFamilyHomologous superfamily

Diseases

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