Entity Details

Primary name HDAC6_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ9Z2V5
EntryNameHDAC6_MOUSE
FullNameHistone deacetylase 6
TaxID10090
Evidenceevidence at protein level
Length1149
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesHdac6

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0000209 protein polyubiquitination
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003779 actin binding
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005901 caveola
GO:0006476 protein deacetylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006515 protein quality control for misfolded or incompletely synthesized proteins
GO:0006886 intracellular protein transport
GO:0007026 negative regulation of microtubule depolymerization
GO:0008013 beta-catenin binding
GO:0008017 microtubule binding
GO:0008270 zinc ion binding
GO:0010634 positive regulation of epithelial cell migration
GO:0015630 microtubule cytoskeleton
GO:0016234 inclusion body
GO:0016235 aggresome
GO:0016241 regulation of macroautophagy
GO:0016575 histone deacetylation
GO:0019213 deacetylase activity
GO:0030286 dynein complex
GO:0030424 axon
GO:0030425 dendrite
GO:0031252 cell leading edge
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0031625 ubiquitin protein ligase binding
GO:0031647 regulation of protein stability
GO:0031648 protein destabilization
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032418 lysosome localization
GO:0032984 protein-containing complex disassembly
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033558 protein deacetylase activity
GO:0034983 peptidyl-lysine deacetylation
GO:0035967 cellular response to topologically incorrect protein
GO:0040029 regulation of gene expression, epigenetic
GO:0042826 histone deacetylase binding
GO:0042903 tubulin deacetylase activity
GO:0043005 neuron projection
GO:0043014 alpha-tubulin binding
GO:0043130 ubiquitin binding
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043204 perikaryon
GO:0043242 negative regulation of protein-containing complex disassembly
GO:0044297 cell body
GO:0045598 regulation of fat cell differentiation
GO:0045861 negative regulation of proteolysis
GO:0048156 tau protein binding
GO:0048471 perinuclear region of cytoplasm
GO:0048487 beta-tubulin binding
GO:0048668 collateral sprouting
GO:0051646 mitochondrion localization
GO:0051787 misfolded protein binding
GO:0051788 response to misfolded protein
GO:0051879 Hsp90 protein binding
GO:0060997 dendritic spine morphogenesis
GO:0061734 parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:0070201 regulation of establishment of protein localization
GO:0070301 cellular response to hydrogen peroxide
GO:0070840 dynein complex binding
GO:0070842 aggresome assembly
GO:0070845 polyubiquitinated misfolded protein transport
GO:0070846 Hsp90 deacetylation
GO:0070848 response to growth factor
GO:0071218 cellular response to misfolded protein
GO:0090042 tubulin deacetylation
GO:0098779 positive regulation of mitophagy in response to mitochondrial depolarization
GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death
GO:2000273 positive regulation of signaling receptor activity

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm
Nucleus
Perikaryon

Domains

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DomainNameCategoryType
IPR000286 Histone deacetylase familyFamilyFamily
IPR001607 Zinc finger, UBP-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR023696 Ureohydrolase domain superfamilyFamilyHomologous superfamily
IPR023801 Histone deacetylase domainDomainDomain
IPR037138 Histone deacetylase domain superfamilyFamilyHomologous superfamily

Diseases

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