Entity Details

Primary name ACTN3_MOUSE
Entity type UniProt
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Details

AccessionO88990
EntryNameACTN3_MOUSE
FullNameAlpha-actinin-3
TaxID10090
Evidenceevidence at transcript level
Length900
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesActn3

GO terms

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GOName
GO:0005509 calcium ion binding
GO:0005865 striated muscle thin filament
GO:0005903 brush border
GO:0006936 muscle contraction
GO:0014728 regulation of the force of skeletal muscle contraction
GO:0014732 skeletal muscle atrophy
GO:0014883 transition between fast and slow fiber
GO:0014894 response to denervation involved in regulation of muscle adaptation
GO:0030017 sarcomere
GO:0030018 Z disc
GO:0030674 protein-macromolecule adaptor activity
GO:0031448 positive regulation of fast-twitch skeletal muscle fiber contraction
GO:0045820 negative regulation of glycolytic process
GO:0048633 positive regulation of skeletal muscle tissue growth
GO:0048743 positive regulation of skeletal muscle fiber development
GO:0051015 actin filament binding
GO:0060349 bone morphogenesis
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0090257 regulation of muscle system process
GO:0090324 negative regulation of oxidative phosphorylation
GO:0120163 negative regulation of cold-induced thermogenesis
GO:1900159 positive regulation of bone mineralization involved in bone maturation
GO:1901078 negative regulation of relaxation of muscle
GO:1903715 regulation of aerobic respiration
GO:1904025 positive regulation of glucose catabolic process to lactate via pyruvate

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001589 Actinin-type actin-binding domain, conserved siteSiteConserved site
IPR001715 Calponin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR014837 EF-hand, Ca insensitiveDomainDomain
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR036872 CH domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

3 interactions