Entity Details

Primary name HACL2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionA1L0T0
EntryNameHACL2_HUMAN
FullName2-hydroxyacyl-CoA lyase 2
TaxID9606
Evidenceevidence at protein level
Length632
SequenceStatuscomplete
DateCreated2008-01-15
DateModified2021-06-02

Ontological Relatives

GenesILVBL

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001561 fatty acid alpha-oxidation
GO:0003984 acetolactate synthase activity
GO:0005789 endoplasmic reticulum membrane
GO:0005948 acetolactate synthase complex
GO:0009097 isoleucine biosynthetic process
GO:0009099 valine biosynthetic process
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016829 lyase activity
GO:0030976 thiamine pyrophosphate binding
GO:0050660 flavin adenine dinucleotide binding

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000399 TPP-binding enzyme, conserved siteSiteConserved site
IPR011766 Thiamine pyrophosphate enzyme, C-terminal TPP-bindingDomainDomain
IPR012000 Thiamine pyrophosphate enzyme, central domainDomainDomain
IPR012001 Thiamine pyrophosphate enzyme, N-terminal TPP-binding domainDomainDomain
IPR029035 DHS-like NAD/FAD-binding domain superfamilyFamilyHomologous superfamily
IPR029061 Thiamin diphosphate-binding foldFamilyHomologous superfamily

Diseases

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Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink