Entity Details

Primary name DYR_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP00375
EntryNameDYR_MOUSE
FullNameDihydrofolate reductase
TaxID10090
Evidenceevidence at protein level
Length187
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesDhfr

GO terms

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GOName
GO:0000900 translation repressor activity, mRNA regulatory element binding
GO:0003729 mRNA binding
GO:0004146 dihydrofolate reductase activity
GO:0005542 folic acid binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006545 glycine biosynthetic process
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0008144 drug binding
GO:0017148 negative regulation of translation
GO:0031103 axon regeneration
GO:0031427 response to methotrexate
GO:0035094 response to nicotine
GO:0046452 dihydrofolate metabolic process
GO:0046653 tetrahydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
GO:0050661 NADP binding
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051870 methotrexate binding
GO:0051871 dihydrofolic acid binding
GO:0070402 NADPH binding
GO:1990825 sequence-specific mRNA binding
GO:2000121 regulation of removal of superoxide radicals

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion

Domains

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DomainNameCategoryType
IPR001796 Dihydrofolate reductase domainDomainDomain
IPR012259 Dihydrofolate reductaseFamilyFamily
IPR017925 Dihydrofolate reductase conserved siteSiteConserved site
IPR024072 Dihydrofolate reductase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

0 interactions

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