Entity Details

Primary name HPRT_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP00493
EntryNameHPRT_MOUSE
FullNameHypoxanthine-guanine phosphoribosyltransferase
TaxID10090
Evidenceevidence at protein level
Length218
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesHprt

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0001913 T cell mediated cytotoxicity
GO:0001975 response to amphetamine
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006164 purine nucleotide biosynthetic process
GO:0006166 purine ribonucleoside salvage
GO:0006168 adenine salvage
GO:0006178 guanine salvage
GO:0007625 grooming behavior
GO:0007626 locomotory behavior
GO:0021756 striatum development
GO:0021895 cerebral cortex neuron differentiation
GO:0021954 central nervous system neuron development
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0042417 dopamine metabolic process
GO:0042802 identical protein binding
GO:0043103 hypoxanthine salvage
GO:0045964 positive regulation of dopamine metabolic process
GO:0046038 GMP catabolic process
GO:0046040 IMP metabolic process
GO:0046083 adenine metabolic process
GO:0046100 hypoxanthine metabolic process
GO:0046651 lymphocyte proliferation
GO:0048813 dendrite morphogenesis
GO:0051289 protein homotetramerization
GO:0052657 guanine phosphoribosyltransferase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000836 Phosphoribosyltransferase domainDomainDomain
IPR005904 Hypoxanthine phosphoribosyl transferaseFamilyFamily
IPR029057 Phosphoribosyltransferase-likeFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
HPRT_MOUSEHPRT_MOUSEMINT11591653 details
HPRT_MOUSEITA2B_MOUSEBioGRID30333137 details