Entity Details

Primary name CNOT1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionA5YKK6
EntryNameCNOT1_HUMAN
FullNameCCR4-NOT transcription complex subunit 1
TaxID9606
Evidenceevidence at protein level
Length2376
SequenceStatuscomplete
DateCreated2008-01-15
DateModified2021-06-02

Ontological Relatives

GenesCNOT1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000932 P-body
GO:0001829 trophectodermal cell differentiation
GO:0003723 RNA binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly
GO:0016020 membrane
GO:0017148 negative regulation of translation
GO:0019904 protein domain specific binding
GO:0030014 CCR4-NOT complex
GO:0030015 CCR4-NOT core complex
GO:0030331 estrogen receptor binding
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0035195 gene silencing by miRNA
GO:0042974 retinoic acid receptor binding
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0060090 molecular adaptor activity
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0061014 positive regulation of mRNA catabolic process
GO:0070016 armadillo repeat domain binding
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000036 regulation of stem cell population maintenance

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR007196 CCR4-Not complex component, Not1, C-terminalDomainDomain
IPR016021 MIF4G-like domain superfamilyFamilyHomologous superfamily
IPR024557 CCR4-Not complex, Not1 subunit, domain of unknown function DUF3819DomainDomain
IPR032191 CCR4-NOT transcription complex subunit 1, CAF1-binding domainDomainDomain
IPR032193 CCR4-NOT transcription complex subunit 1, TTP binding domainDomainDomain
IPR032194 CCR4-NOT transcription complex subunit 1, HEAT repeatDomainDomain
IPR038535 CCR4-NOT subunit 1, TTP binding domain superfamilyFamilyHomologous superfamily
IPR040398 CCR4-NOT transcription complex subunit 1FamilyFamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CNOT1_HUMANESR1_MOUSEBioGRID, MINT16778766 details
CNOT1_HUMANTTP_MOUSEUniProt21278420 details