Entity Details

Primary name EGF_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP01132
EntryNameEGF_MOUSE
FullNamePro-epidermal growth factor
TaxID10090
Evidenceevidence at protein level
Length1217
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesEgf

GO terms

Show/Hide Table
GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0000187 obsolete activation of MAPK activity
GO:0001525 angiogenesis
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002092 positive regulation of receptor internalization
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008083 growth factor activity
GO:0008284 positive regulation of cell population proliferation
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016021 integral component of membrane
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation
GO:0030335 positive regulation of cell migration
GO:0038029 epidermal growth factor receptor signaling pathway via MAPK cascade
GO:0042327 positive regulation of phosphorylation
GO:0043388 positive regulation of DNA binding
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0045740 positive regulation of DNA replication
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045840 positive regulation of mitotic nuclear division
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0048146 positive regulation of fibroblast proliferation
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050708 regulation of protein secretion
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051048 negative regulation of secretion
GO:0051223 regulation of protein transport
GO:0051897 positive regulation of protein kinase B signaling
GO:0060749 mammary gland alveolus development
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070062 extracellular exosome
GO:0070371 ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090279 regulation of calcium ion import
GO:0090370 negative regulation of cholesterol efflux
GO:1900127 positive regulation of hyaluronan biosynthetic process
GO:1902966 positive regulation of protein localization to early endosome
GO:1905278 positive regulation of epithelial tube formation
GO:2000008 regulation of protein localization to cell surface
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2000573 positive regulation of DNA biosynthetic process

Subcellular Location

Show/Hide Table
Subcellular Location
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000033 LDLR class B repeatRepeatRepeat
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR016317 Pro-epidermal growth factorFamilyFamily
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site

Diseases

Show/Hide Table