Entity Details

Primary name IL1A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionP01582
EntryNameIL1A_MOUSE
FullNameInterleukin-1 alpha
TaxID10090
Evidenceevidence at protein level
Length270
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesIl1a

GO terms

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GOName
GO:0001660 fever generation
GO:0001819 positive regulation of cytokine production
GO:0002248 connective tissue replacement involved in inflammatory response wound healing
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
GO:0005507 copper ion binding
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006883 cellular sodium ion homeostasis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0008285 negative regulation of cell population proliferation
GO:0009986 cell surface
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010628 positive regulation of gene expression
GO:0010893 positive regulation of steroid biosynthetic process
GO:0019221 cytokine-mediated signaling pathway
GO:0031424 keratinization
GO:0032308 positive regulation of prostaglandin secretion
GO:0032743 positive regulation of interleukin-2 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032956 regulation of actin cytoskeleton organization
GO:0033092 positive regulation of immature T cell proliferation in thymus
GO:0034605 cellular response to heat
GO:0035234 ectopic germ cell programmed cell death
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045766 positive regulation of angiogenesis
GO:0045840 positive regulation of mitotic nuclear division
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046688 response to copper ion
GO:0050714 positive regulation of protein secretion
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051781 positive regulation of cell division
GO:0051930 regulation of sensory perception of pain
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071222 cellular response to lipopolysaccharide
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1902624 positive regulation of neutrophil migration
GO:1904445 negative regulation of establishment of Sertoli cell barrier

Subcellular Location

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Subcellular Location
Cytoplasm
Secreted

Domains

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DomainNameCategoryType
IPR000975 Interleukin-1 familyFamilyFamily
IPR003295 Interleukin-1 alphaFamilyFamily
IPR003502 Interleukin-1 propeptideDomainDomain
IPR008996 Cytokine IL1/FGFFamilyHomologous superfamily
IPR020877 Interleukin-1 conserved siteSiteConserved site

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
IL1A_MOUSEIL1R1_MOUSEBioGRID17507369 details