Entity Details

Primary name SGK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00141
EntryNameSGK1_HUMAN
FullNameSerine/threonine-protein kinase Sgk1
TaxID9606
Evidenceevidence at protein level
Length431
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesSGK1

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005246 calcium channel regulator activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006814 sodium ion transport
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0007616 long-term memory
GO:0008217 regulation of blood pressure
GO:0015459 potassium channel regulator activity
GO:0016607 nuclear speck
GO:0017080 sodium channel regulator activity
GO:0017081 chloride channel regulator activity
GO:0018105 peptidyl-serine phosphorylation
GO:0030334 regulation of cell migration
GO:0032411 positive regulation of transporter activity
GO:0034220 ion transmembrane transport
GO:0035556 intracellular signal transduction
GO:0042127 regulation of cell population proliferation
GO:0042981 regulation of apoptotic process
GO:0048812 neuron projection morphogenesis
GO:0050790 regulation of catalytic activity
GO:0051090 regulation of DNA-binding transcription factor activity
GO:0060453 regulation of gastric acid secretion
GO:0070294 renal sodium ion absorption
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904045 cellular response to aldosterone

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endoplasmic reticulum membrane
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB03247 Flavin mononucleotideDrugbanksmall molecule
DB07837 [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acidDrugbanksmall molecule
DB08191 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acidDrugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
SGK1_HUMANPRAF1_MOUSEBioGRID, IntAct20368287 details
SGK1_HUMANTM109_MOUSEBioGRID, IntAct20368287 details
SGK1_HUMANWNK4_MOUSEDIP17360471 details