Entity Details

Primary name TLR4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00206
EntryNameTLR4_HUMAN
FullNameToll-like receptor 4
TaxID9606
Evidenceevidence at protein level
Length839
SequenceStatuscomplete
DateCreated2002-02-11
DateModified2021-06-02

Ontological Relatives

GenesTLR4

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001530 lipopolysaccharide binding
GO:0001540 amyloid-beta binding
GO:0001726 ruffle
GO:0001875 lipopolysaccharide immune receptor activity
GO:0001891 phagocytic cup
GO:0002218 activation of innate immune response
GO:0002224 toll-like receptor signaling pathway
GO:0002322 B cell proliferation involved in immune response
GO:0002537 nitric oxide production involved in inflammatory response
GO:0002730 regulation of dendritic cell cytokine production
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0004888 transmembrane signaling receptor activity
GO:0005102 signaling receptor binding
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007252 I-kappaB phosphorylation
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0010572 positive regulation of platelet activation
GO:0010628 positive regulation of gene expression
GO:0010838 positive regulation of keratinocyte proliferation
GO:0014002 astrocyte development
GO:0016046 detection of fungus
GO:0030890 positive regulation of B cell proliferation
GO:0031226 intrinsic component of plasma membrane
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032497 detection of lipopolysaccharide
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032707 negative regulation of interleukin-23 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032722 positive regulation of chemokine production
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0032729 positive regulation of interferon-gamma production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032732 positive regulation of interleukin-1 production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0034128 negative regulation of MyD88-independent toll-like receptor signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038023 signaling receptor activity
GO:0042088 T-helper 1 type immune response
GO:0042116 macrophage activation
GO:0042742 defense response to bacterium
GO:0042802 identical protein binding
GO:0043032 positive regulation of macrophage activation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043235 receptor complex
GO:0045087 innate immune response
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045671 negative regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046330 positive regulation of JNK cascade
GO:0046696 lipopolysaccharide receptor complex
GO:0046982 protein heterodimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0050135 NAD(P)+ nucleosidase activity
GO:0050729 positive regulation of inflammatory response
GO:0050829 defense response to Gram-negative bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060729 intestinal epithelial structure maintenance
GO:0060907 positive regulation of macrophage cytokine production
GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
GO:0070266 necroptotic process
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070430 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0071223 cellular response to lipoteichoic acid
GO:0071260 cellular response to mechanical stimulus
GO:0071346 cellular response to interferon-gamma
GO:0097190 apoptotic signaling pathway
GO:0120163 negative regulation of cold-induced thermogenesis
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900017 positive regulation of cytokine production involved in inflammatory response
GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1903223 positive regulation of oxidative stress-induced neuron death
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1903974 positive regulation of cellular response to macrophage colony-stimulating factor stimulus
GO:1904466 positive regulation of matrix metallopeptidase secretion
GO:1904646 cellular response to amyloid-beta
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Early endosome

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR000483 Cysteine-rich flanking region, C-terminalDomainDomain
IPR001611 Leucine-rich repeatRepeatRepeat
IPR003591 Leucine-rich repeat, typical subtypeRepeatRepeat
IPR017241 Toll-like receptorFamilyFamily
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00924 CyclobenzaprineDrugbanksmall molecule
DB01183 NaloxoneDrugbanksmall molecule
DB02767 (R)-3-hydroxytetradecanoic acidDrugbanksmall molecule
DB03017 Lauric acidDrugbanksmall molecule
DB04933 EritoranDrugbanksmall molecule
DB05475 GolotimodDrugbanksmall molecule
DB06447 E5531Drugbanksmall molecule
DB08231 Myristic acidDrugbanksmall molecule
DB11193 PapainDrugbanksmall molecule
DB13615 MifamurtideDrugbanksmall molecule

Interactions

0 interactions

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