Entity Details

Primary name BMR1B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00238
EntryNameBMR1B_HUMAN
FullNameBone morphogenetic protein receptor type-1B
TaxID9606
Evidenceevidence at protein level
Length502
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesBMPR1B

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001502 cartilage condensation
GO:0001550 ovarian cumulus expansion
GO:0001649 osteoblast differentiation
GO:0001654 eye development
GO:0002063 chondrocyte development
GO:0004674 protein serine/threonine kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005025 transforming growth factor beta receptor activity, type I
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0009953 dorsal/ventral pattern formation
GO:0030166 proteoglycan biosynthetic process
GO:0030425 dendrite
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031290 retinal ganglion cell axon guidance
GO:0032332 positive regulation of chondrocyte differentiation
GO:0035108 limb morphogenesis
GO:0036122 BMP binding
GO:0042698 ovulation cycle
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0045597 positive regulation of cell differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0060041 retina development in camera-type eye
GO:0060350 endochondral bone morphogenesis
GO:0061036 positive regulation of cartilage development
GO:0071363 cellular response to growth factor stimulus
GO:0071773 cellular response to BMP stimulus
GO:0098821 BMP receptor activity
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902731 negative regulation of chondrocyte proliferation
GO:1990712 HFE-transferrin receptor complex

Subcellular Location

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Subcellular Location
Cell membrane
Membrane

Domains

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DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000472 Activin types I and II receptor domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003605 GS domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
BMR1B_HUMANUBXN1_MOUSEMINT15761153 details
BMR1B_HUMANSASH3_MOUSEMINT15761153 details