Entity Details

Primary name HIP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00291
EntryNameHIP1_HUMAN
FullNameHuntingtin-interacting protein 1
TaxID9606
Evidenceevidence at protein level
Length1037
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesHIP1

GO terms

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GOName
GO:0005154 epidermal growth factor receptor binding
GO:0005200 structural constituent of cytoskeleton
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0006897 endocytosis
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007015 actin filament organization
GO:0016020 membrane
GO:0030100 regulation of endocytosis
GO:0030136 clathrin-coated vesicle
GO:0030154 cell differentiation
GO:0030276 clathrin binding
GO:0030665 clathrin-coated vesicle membrane
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032051 clathrin light chain binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0035091 phosphatidylinositol binding
GO:0035254 glutamate receptor binding
GO:0035612 AP-2 adaptor complex binding
GO:0035615 clathrin adaptor activity
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0046982 protein heterodimerization activity
GO:0048260 positive regulation of receptor-mediated endocytosis
GO:0048268 clathrin coat assembly
GO:0050821 protein stabilization
GO:0051015 actin filament binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0061024 membrane organization
GO:0072583 clathrin-dependent endocytosis
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
GO:0097190 apoptotic signaling pathway
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0098888 extrinsic component of presynaptic membrane
GO:0098890 extrinsic component of postsynaptic membrane
GO:0098978 glutamatergic synapse
GO:0099637 neurotransmitter receptor transport
GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Endomembrane system
Nucleus

Domains

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DomainNameCategoryType
IPR002558 I/LWEQ domainDomainDomain
IPR008942 ENTH/VHSFamilyHomologous superfamily
IPR011417 AP180 N-terminal homology (ANTH) domainDomainDomain
IPR013809 ENTH domainDomainDomain
IPR030224 Sla2 familyFamilyFamily
IPR030554 Huntingtin-interacting protein 1FamilyFamily
IPR032422 Huntingtin-interacting protein 1, clathrin-binding domainDomainDomain
IPR035964 I/LWEQ domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
HIP1_HUMANNECP1_MOUSEMINT17762867 details
HIP1_HUMANHIP1R_MOUSEBioGRID15533940 details