Entity Details

Primary name WASL_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00401
EntryNameWASL_HUMAN
FullNameNeural Wiskott-Aldrich syndrome protein
TaxID9606
Evidenceevidence at protein level
Length505
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesWASL

GO terms

Show/Hide Table
GOName
GO:0003779 actin binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0006900 vesicle budding from membrane
GO:0008154 actin polymerization or depolymerization
GO:0009617 response to bacterium
GO:0015629 actin cytoskeleton
GO:0016050 vesicle organization
GO:0030027 lamellipodium
GO:0030041 actin filament polymerization
GO:0030048 actin filament-based movement
GO:0030050 vesicle transport along actin filament
GO:0030478 actin cap
GO:0030666 endocytic vesicle membrane
GO:0030695 GTPase regulator activity
GO:0031410 cytoplasmic vesicle
GO:0032880 regulation of protein localization
GO:0034629 cellular protein-containing complex localization
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048013 ephrin receptor signaling pathway
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051301 cell division
GO:0051491 positive regulation of filopodium assembly
GO:0051653 spindle localization
GO:0060997 dendritic spine morphogenesis
GO:0061024 membrane organization
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:1903526 negative regulation of membrane tubulation
GO:2000370 positive regulation of clathrin-dependent endocytosis
GO:2000402 negative regulation of lymphocyte migration
GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000095 CRIB domainDomainDomain
IPR000697 WH1/EVH1 domainDomainDomain
IPR003124 WH2 domainDomainDomain
IPR011026 Wiscott-Aldrich syndrome protein, C-terminalFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR030214 Neural Wiskott-Aldrich syndrome proteinFamilyFamily
IPR033927 WASP family, EVH1 domainDomainDomain
IPR036936 CRIB domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
WASL_HUMANSPN90_MOUSEMINT11157975 details
WASL_HUMANITSN1_MOUSEMINT15824104 details