Entity Details

Primary name P85B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00459
EntryNameP85B_HUMAN
FullNamePhosphatidylinositol 3-kinase regulatory subunit beta
TaxID9606
Evidenceevidence at protein level
Length728
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesPIK3R2

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0001678 cellular glucose homeostasis
GO:0001784 phosphotyrosine residue binding
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0006661 phosphatidylinositol biosynthetic process
GO:0008286 insulin receptor signaling pathway
GO:0010506 regulation of autophagy
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0015031 protein transport
GO:0019903 protein phosphatase binding
GO:0030971 receptor tyrosine kinase binding
GO:0032869 cellular response to insulin stimulus
GO:0034976 response to endoplasmic reticulum stress
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042307 positive regulation of protein import into nucleus
GO:0043409 negative regulation of MAPK cascade
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
GO:0046982 protein heterodimerization activity
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051897 positive regulation of protein kinase B signaling

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000198 Rho GTPase-activating protein domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008936 Rho GTPase activation proteinFamilyHomologous superfamily
IPR032498 PI3K regulatory subunit p85-related , inter-SH2 domainDomainDomain
IPR035020 PI3K p85 subunit, C-terminal SH2 domainDomainDomain
IPR035022 PI3K p85 subunit, N-terminal SH2 domainDomainDomain
IPR035586 Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01064 IsoprenalineDrugbanksmall molecule
DB05210 SF1126Drugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
P85B_HUMANMBP_MOUSEBioGRID, MINT18067320 details