Entity Details

Primary name DDX3X_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO00571
EntryNameDDX3X_HUMAN
FullNameATP-dependent RNA helicase DDX3X
TaxID9606
Evidenceevidence at protein level
Length662
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesDDX3X

GO terms

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GOName
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003729 mRNA binding
GO:0003924 GTPase activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006413 translational initiation
GO:0007059 chromosome segregation
GO:0007276 gamete generation
GO:0008134 transcription factor binding
GO:0008143 poly(A) binding
GO:0008190 eukaryotic initiation factor 4E binding
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009615 response to virus
GO:0010494 cytoplasmic stress granule
GO:0010501 RNA secondary structure unwinding
GO:0010628 positive regulation of gene expression
GO:0016032 viral process
GO:0016055 Wnt signaling pathway
GO:0016887 ATP hydrolysis activity
GO:0017111 nucleoside-triphosphatase activity
GO:0017148 negative regulation of translation
GO:0030027 lamellipodium
GO:0030154 cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0031252 cell leading edge
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031369 translation initiation factor binding
GO:0031954 positive regulation of protein autophosphorylation
GO:0032727 positive regulation of interferon-alpha production
GO:0032728 positive regulation of interferon-beta production
GO:0033592 RNA strand annealing activity
GO:0034063 stress granule assembly
GO:0034157 positive regulation of toll-like receptor 7 signaling pathway
GO:0034161 positive regulation of toll-like receptor 8 signaling pathway
GO:0034774 secretory granule lumen
GO:0035556 intracellular signal transduction
GO:0035613 RNA stem-loop binding
GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress
GO:0042256 mature ribosome assembly
GO:0043015 gamma-tubulin binding
GO:0043024 ribosomal small subunit binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043186 P granule
GO:0043273 CTPase activity
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043312 neutrophil degranulation
GO:0043539 protein serine/threonine kinase activator activity
GO:0045070 positive regulation of viral genome replication
GO:0045087 innate immune response
GO:0045296 cadherin binding
GO:0045727 positive regulation of translation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045948 positive regulation of translational initiation
GO:0048027 mRNA 5'-UTR binding
GO:0055088 lipid homeostasis
GO:0070062 extracellular exosome
GO:0071243 cellular response to arsenic-containing substance
GO:0071470 cellular response to osmotic stress
GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072559 NLRP3 inflammasome complex
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:0098586 cellular response to virus
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1900227 positive regulation of NLRP3 inflammasome complex assembly
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1901224 positive regulation of NIK/NF-kappaB signaling
GO:1901985 positive regulation of protein acetylation
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902523 positive regulation of protein K63-linked ubiquitination
GO:1903608 protein localization to cytoplasmic stress granule
GO:1904813 ficolin-1-rich granule lumen
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Inflammasome
Nucleus

Domains

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DomainNameCategoryType
IPR000629 ATP-dependent RNA helicase DEAD-box, conserved siteSiteConserved site
IPR001650 Helicase, C-terminalDomainDomain
IPR011545 DEAD/DEAH box helicase domainDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR014014 RNA helicase, DEAD-box type, Q motifDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
DDX3X_HUMANTRPM7_MOUSEIntAct24855944 details
DDX3X_HUMANMK13_MOUSEBioGRID19135240 details