Entity Details

Primary name SOCS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14508
EntryNameSOCS2_HUMAN
FullNameSuppressor of cytokine signaling 2
TaxID9606
Evidenceevidence at protein level
Length198
SequenceStatuscomplete
DateCreated2002-04-16
DateModified2021-06-02

Ontological Relatives

GenesSOCS2

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0005131 growth hormone receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007595 lactation
GO:0008269 JAK pathway signal transduction adaptor activity
GO:0009966 regulation of signal transduction
GO:0016567 protein ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0032355 response to estradiol
GO:0032870 cellular response to hormone stimulus
GO:0035556 intracellular signal transduction
GO:0038111 interleukin-7-mediated signaling pathway
GO:0040015 negative regulation of multicellular organism growth
GO:0043066 negative regulation of apoptotic process
GO:0043687 post-translational protein modification
GO:0045666 positive regulation of neuron differentiation
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
GO:0060396 growth hormone receptor signaling pathway
GO:0060749 mammary gland alveolus development

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001496 SOCS box domainDomainDomain
IPR028410 Suppressor of cytokine signalling 2FamilyFamily
IPR035862 SOCS2, SH2 domainDomainDomain
IPR036036 SOCS box-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
SOCS2_HUMANELOC_MOUSEBioGRID, IntAct19159283 23897481 details