Entity Details

Primary name SOCS3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14543
EntryNameSOCS3_HUMAN
FullNameSuppressor of cytokine signaling 3
TaxID9606
Evidenceevidence at protein level
Length225
SequenceStatuscomplete
DateCreated2002-04-16
DateModified2021-06-02

Ontological Relatives

GenesSOCS3

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0004860 protein kinase inhibitor activity
GO:0005829 cytosol
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0016567 protein ubiquitination
GO:0019221 cytokine-mediated signaling pathway
GO:0035556 intracellular signal transduction
GO:0040008 regulation of growth
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0043066 negative regulation of apoptotic process
GO:0043687 post-translational protein modification
GO:0045597 positive regulation of cell differentiation
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046935 1-phosphatidylinositol-3-kinase regulator activity
GO:0050728 negative regulation of inflammatory response
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060670 branching involved in labyrinthine layer morphogenesis
GO:0060674 placenta blood vessel development
GO:0060707 trophoblast giant cell differentiation
GO:0060708 spongiotrophoblast differentiation
GO:0070102 interleukin-6-mediated signaling pathway
GO:1990830 cellular response to leukemia inhibitory factor

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001496 SOCS box domainDomainDomain
IPR028414 Suppressor of cytokine signalling 3FamilyFamily
IPR035863 SOCS3, SH2 domainDomainDomain
IPR036036 SOCS box-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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