Entity Details

Primary name DVL2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14641
EntryNameDVL2_HUMAN
FullNameSegment polarity protein dishevelled homolog DVL-2
TaxID9606
Evidenceevidence at protein level
Length736
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesDVL2

GO terms

Show/Hide Table
GOName
GO:0001843 neural tube closure
GO:0005829 cytosol
GO:0016235 aggresome
GO:0016328 lateral plasma membrane
GO:0042802 identical protein binding
GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation
GO:0045334 clathrin-coated endocytic vesicle
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090103 cochlea morphogenesis
GO:0150012 positive regulation of neuron projection arborization
GO:0003151 outflow tract morphogenesis
GO:0007507 heart development
GO:0016604 nuclear body
GO:0034613 cellular protein localization
GO:0043621 protein self-association
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061024 membrane organization
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0007379 segment specification
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030674 protein-macromolecule adaptor activity
GO:0031410 cytoplasmic vesicle
GO:0035567 non-canonical Wnt signaling pathway
GO:0043507 positive regulation of JUN kinase activity
GO:0045177 apical part of cell
GO:0090179 planar cell polarity pathway involved in neural tube closure
GO:0001934 positive regulation of protein phosphorylation
GO:0005109 frizzled binding
GO:0005634 nucleus
GO:0022007 convergent extension involved in neural plate elongation
GO:0031267 small GTPase binding
GO:0031343 positive regulation of cell killing
GO:0035329 hippo signaling
GO:0043547 positive regulation of GTPase activity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060070 canonical Wnt signaling pathway
GO:1904886 beta-catenin destruction complex disassembly

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cytoplasmic vesicle
Nucleus
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000591 DEP domainDomainDomain
IPR001158 DIX domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR003351 Dishevelled protein domainDomainDomain
IPR008339 Dishevelled familyFamilyFamily
IPR008341 Dishevelled-2FamilyFamily
IPR015506 Dishevelled-related proteinFamilyFamily
IPR024580 Dishevelled C-terminalDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR038207 DIX domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table