Entity Details

Primary name ADA10_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14672
EntryNameADA10_HUMAN
FullNameDisintegrin and metalloproteinase domain-containing protein 10
TaxID9606
Evidenceevidence at protein level
Length748
SequenceStatuscomplete
DateCreated2003-02-28
DateModified2021-06-02

Ontological Relatives

GenesADAM10

GO terms

Show/Hide Table
GOName
GO:0000139 Golgi membrane
GO:0001701 in utero embryonic development
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0005102 signaling receptor binding
GO:0005178 integrin binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005788 endoplasmic reticulum lumen
GO:0005794 Golgi apparatus
GO:0005798 Golgi-associated vesicle
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0006509 membrane protein ectodomain proteolysis
GO:0007162 negative regulation of cell adhesion
GO:0007219 Notch signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007267 cell-cell signaling
GO:0007283 spermatogenesis
GO:0008021 synaptic vesicle
GO:0008237 metallopeptidase activity
GO:0008284 positive regulation of cell population proliferation
GO:0008593 regulation of Notch signaling pathway
GO:0009986 cell surface
GO:0010629 negative regulation of gene expression
GO:0010820 positive regulation of T cell chemotaxis
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016485 protein processing
GO:0017124 SH3 domain binding
GO:0019901 protein kinase binding
GO:0022617 extracellular matrix disassembly
GO:0030136 clathrin-coated vesicle
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030424 axon
GO:0034205 amyloid-beta formation
GO:0034332 adherens junction organization
GO:0034612 response to tumor necrosis factor
GO:0035333 Notch receptor processing, ligand-dependent
GO:0035579 specific granule membrane
GO:0042117 monocyte activation
GO:0042803 protein homodimerization activity
GO:0042987 amyloid precursor protein catabolic process
GO:0043025 neuronal cell body
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043197 dendritic spine
GO:0043231 intracellular membrane-bounded organelle
GO:0043312 neutrophil degranulation
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0045211 postsynaptic membrane
GO:0046872 metal ion binding
GO:0046930 pore complex
GO:0046931 pore complex assembly
GO:0051089 constitutive protein ectodomain proteolysis
GO:0061001 regulation of dendritic spine morphogenesis
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:0090102 cochlea development
GO:0097038 perinuclear endoplasmic reticulum
GO:0097060 synaptic membrane
GO:0097197 tetraspanin-enriched microdomain
GO:0097327 response to antineoplastic agent
GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:0098978 glutamatergic synapse
GO:0099173 postsynapse organization
GO:1901342 regulation of vasculature development
GO:1901998 toxin transport
GO:1902945 metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:1990000 amyloid fibril formation

Subcellular Location

Show/Hide Table
Subcellular Location
Cell junction
Cell membrane
Cell projection
Cytoplasm
Cytoplasmic vesicle
Golgi apparatus membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001590 Peptidase M12B, ADAM/reprolysinDomainDomain
IPR001762 Disintegrin domainDomainDomain
IPR002870 Peptidase M12B, propeptideDomainDomain
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR027053 Disintegrin and metalloproteinase domain-containing protein 10FamilyFamily
IPR034025 ADAM10/ADAM17 catalytic domainDomainDomain
IPR036436 Disintegrin domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB04991 XL784Drugbanksmall molecule

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink