Entity Details

Primary name NHRF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14745
EntryNameNHRF1_HUMAN
FullNameNa(+)/H(+) exchange regulatory cofactor NHE-RF1
TaxID9606
Evidenceevidence at protein level
Length358
SequenceStatuscomplete
DateCreated2004-02-02
DateModified2021-06-02

Ontological Relatives

GenesSLC9A3R1

GO terms

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GOName
GO:0001726 ruffle
GO:0002009 morphogenesis of an epithelium
GO:0003096 renal sodium ion transport
GO:0005102 signaling receptor binding
GO:0005737 cytoplasm
GO:0005902 microvillus
GO:0007009 plasma membrane organization
GO:0007097 nuclear migration
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007605 sensory perception of sound
GO:0008013 beta-catenin binding
GO:0008285 negative regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0008361 regulation of cell size
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0012505 endomembrane system
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0015185 gamma-aminobutyric acid transmembrane transporter activity
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016055 Wnt signaling pathway
GO:0016324 apical plasma membrane
GO:0017081 chloride channel regulator activity
GO:0019902 phosphatase binding
GO:0019933 cAMP-mediated signaling
GO:0022612 gland morphogenesis
GO:0030033 microvillus assembly
GO:0030036 actin cytoskeleton organization
GO:0030165 PDZ domain binding
GO:0030175 filopodium
GO:0030336 negative regulation of cell migration
GO:0030643 cellular phosphate ion homeostasis
GO:0031526 brush border membrane
GO:0031528 microvillus membrane
GO:0031698 beta-2 adrenergic receptor binding
GO:0031799 type 2 metabotropic glutamate receptor binding
GO:0031800 type 3 metabotropic glutamate receptor binding
GO:0031982 vesicle
GO:0032415 regulation of sodium:proton antiporter activity
GO:0032416 negative regulation of sodium:proton antiporter activity
GO:0032426 stereocilium tip
GO:0032782 bile acid secretion
GO:0034635 glutathione transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0043495 protein-membrane adaptor activity
GO:0043621 protein self-association
GO:0044062 regulation of excretion
GO:0044782 cilium organization
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0045159 myosin II binding
GO:0045198 establishment of epithelial cell apical/basal polarity
GO:0045199 maintenance of epithelial cell apical/basal polarity
GO:0045859 regulation of protein kinase activity
GO:0045930 negative regulation of mitotic cell cycle
GO:0047485 protein N-terminus binding
GO:0048471 perinuclear region of cytoplasm
GO:0050780 dopamine receptor binding
GO:0051683 establishment of Golgi localization
GO:0051898 negative regulation of protein kinase B signaling
GO:0051939 gamma-aminobutyric acid import
GO:0060088 auditory receptor cell stereocilium organization
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0065003 protein-containing complex assembly
GO:0070062 extracellular exosome
GO:0070293 renal absorption
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070851 growth factor receptor binding
GO:0071944 cell periphery
GO:0072659 protein localization to plasma membrane
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090660 cerebrospinal fluid circulation
GO:0097225 sperm midpiece
GO:0097291 renal phosphate ion absorption
GO:0098739 import across plasma membrane
GO:0098797 plasma membrane protein complex
GO:0150104 transport across blood-brain barrier
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Apical cell membrane
Cell projection
Cytoplasm
Endomembrane system

Domains

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DomainNameCategoryType
IPR001478 PDZ domainDomainDomain
IPR015098 EBP50, C-terminalDomainDomain
IPR017300 Na(+)/H(+) exchange regulatory cofactor NHERF-1/2FamilyFamily
IPR031199 Na(+)/H(+) exchange regulatory cofactor NHERF-1FamilyFamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR041489 PDZ domain 6DomainDomain

Diseases

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Interactions

5 interactions