Entity Details

Primary name IKKB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14920
EntryNameIKKB_HUMAN
FullNameInhibitor of nuclear factor kappa-B kinase subunit beta
TaxID9606
Evidenceevidence at protein level
Length756
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesIKBKB

GO terms

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GOName
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005829 cytosol
GO:0009898 cytoplasmic side of plasma membrane
GO:0016032 viral process
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0042802 identical protein binding
GO:0045121 membrane raft
GO:0045893 positive regulation of transcription, DNA-templated
GO:0097110 scaffold protein binding
GO:0106311 protein threonine kinase activity
GO:1903140 regulation of establishment of endothelial barrier
GO:1990459 transferrin receptor binding
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0035509 negative regulation of myosin-light-chain-phosphatase activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046982 protein heterodimerization activity
GO:0051403 stress-activated MAPK cascade
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005634 nucleus
GO:0006954 inflammatory response
GO:0008384 IkappaB kinase activity
GO:0009615 response to virus
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035631 CD40 receptor complex
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071356 cellular response to tumor necrosis factor
GO:0072659 protein localization to plasma membrane
GO:1903347 negative regulation of bicellular tight junction assembly
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0005524 ATP binding
GO:0008385 IkappaB kinase complex
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0030866 cortical actin cytoskeleton organization
GO:0042325 regulation of phosphorylation
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0050852 T cell receptor signaling pathway
GO:0106310 protein serine kinase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane raft
Nucleus

Domains

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DomainNameCategoryType
IPR000626 Ubiquitin-like domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR022007 I-kappa-kinase-beta NEMO binding domainDomainDomain
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR041185 IKBKB, scaffold dimerization domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00244 MesalazineDrugbanksmall molecule
DB00795 SulfasalazineDrugbanksmall molecule
DB00945 Acetylsalicylic acidDrugbanksmall molecule
DB00995 AuranofinDrugbanksmall molecule
DB01169 Arsenic trioxideDrugbanksmall molecule
DB05183 MLN0415Drugbanksmall molecule
DB06151 AcetylcysteineDrugbanksmall molecule
DB06521 ErtiprotafibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

5 interactions