Entity Details

Primary name HGS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14964
EntryNameHGS_HUMAN
FullNameHepatocyte growth factor-regulated tyrosine kinase substrate
TaxID9606
Evidenceevidence at protein level
Length777
SequenceStatuscomplete
DateCreated2005-07-19
DateModified2021-06-02

Ontological Relatives

GenesHGS

GO terms

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GOName
GO:0005764 lysosome
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0006622 protein targeting to lysosome
GO:0006892 post-Golgi vesicle-mediated transport
GO:0007165 signal transduction
GO:0008285 negative regulation of cell population proliferation
GO:0010324 membrane invagination
GO:0010628 positive regulation of gene expression
GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0016197 endosomal transport
GO:0016236 macroautophagy
GO:0016525 negative regulation of angiogenesis
GO:0016579 protein deubiquitination
GO:0019904 protein domain specific binding
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031901 early endosome membrane
GO:0032585 multivesicular body membrane
GO:0033565 ESCRT-0 complex
GO:0036258 multivesicular body assembly
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042176 regulation of protein catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0043405 regulation of MAP kinase activity
GO:0044003 modulation by symbiont of host process
GO:0044389 ubiquitin-like protein ligase binding
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0046872 metal ion binding
GO:0061024 membrane organization
GO:0070062 extracellular exosome
GO:0072657 protein localization to membrane
GO:0097013 phagocytic vesicle lumen
GO:1903543 positive regulation of exosomal secretion

Subcellular Location

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Subcellular Location
Cytoplasm
Early endosome membrane
Endosome

Domains

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DomainNameCategoryType
IPR000306 FYVE zinc fingerDomainDomain
IPR002014 VHS domainDomainDomain
IPR003903 Ubiquitin interacting motifSiteConserved site
IPR008942 ENTH/VHSFamilyHomologous superfamily
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR017073 Ubiquitin binding protein, Hrs/VPS27FamilyFamily
IPR017455 Zinc finger, FYVE-relatedDomainDomain
IPR024641 Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB04272 Citric acidDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
HGS_HUMANSTAM2_MOUSEUniProt15113837 details