Entity Details

Primary name AURKA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO14965
EntryNameAURKA_HUMAN
FullNameAurora kinase A
TaxID9606
Evidenceevidence at protein level
Length403
SequenceStatuscomplete
DateCreated2003-01-27
DateModified2021-06-02

Ontological Relatives

GenesAURKA

GO terms

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GOName
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005929 cilium
GO:0006468 protein phosphorylation
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007051 spindle organization
GO:0007052 mitotic spindle organization
GO:0007057 spindle assembly involved in female meiosis I
GO:0007100 mitotic centrosome separation
GO:0009611 response to wounding
GO:0009948 anterior/posterior axis specification
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0010629 negative regulation of gene expression
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0015630 microtubule cytoskeleton
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0030496 midbody
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031616 spindle pole centrosome
GO:0031625 ubiquitin protein ligase binding
GO:0031647 regulation of protein stability
GO:0032091 negative regulation of protein binding
GO:0032133 chromosome passenger complex
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032465 regulation of cytokinesis
GO:0035174 histone serine kinase activity
GO:0042585 germinal vesicle
GO:0043066 negative regulation of apoptotic process
GO:0043203 axon hillock
GO:0045120 pronucleus
GO:0045840 positive regulation of mitotic nuclear division
GO:0046605 regulation of centrosome cycle
GO:0046777 protein autophosphorylation
GO:0046982 protein heterodimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0051233 spindle midzone
GO:0051301 cell division
GO:0051642 centrosome localization
GO:0071539 protein localization to centrosome
GO:0072687 meiotic spindle
GO:0097421 liver regeneration
GO:0097431 mitotic spindle pole
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900195 positive regulation of oocyte maturation
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1990138 neuron projection extension

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR030611 Aurora kinase ADomainDomain
IPR030616 Aurora kinaseFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB02482 PhosphonothreonineDrugbanksmall molecule
DB05169 AT9283Drugbanksmall molecule
DB05198 CYC116Drugbanksmall molecule
DB05220 AlisertibDrugbanksmall molecule
DB06134 SNS-314Drugbanksmall molecule
DB06347 CenisertibDrugbanksmall molecule
DB06486 EnzastaurinDrugbanksmall molecule
DB07186 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDEDrugbanksmall molecule
DB07266 AKI-001Drugbanksmall molecule
DB07360 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]ureaDrugbanksmall molecule
DB07362 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]ureaDrugbanksmall molecule
DB07545 N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDEDrugbanksmall molecule
DB07801 N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamideDrugbanksmall molecule
DB08065 2-(1H-pyrazol-3-yl)-1H-benzimidazoleDrugbanksmall molecule
DB08066 N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDEDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB13061 MLN8054Drugbanksmall molecule

Interactions

3 interactions

InteractorPartnerSourcesPublicationsLink
AURKA_HUMANINCE_MOUSEBioGRID, IntAct11050385 20360068 details
AURKA_HUMANMIME_MOUSEmatrixdb20375348 details
AURKA_HUMANSIR2_MOUSEBioGRID, IntAct22014574 details