Entity Details

Primary name AREL1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15033
EntryNameAREL1_HUMAN
FullNameApoptosis-resistant E3 ubiquitin protein ligase 1
TaxID9606
Evidenceevidence at protein level
Length823
SequenceStatuscomplete
DateCreated2005-03-29
DateModified2021-06-02

Ontological Relatives

GenesAREL1

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0004842 ubiquitin-protein transferase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0016567 protein ubiquitination
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045732 positive regulation of protein catabolic process
GO:0050727 regulation of inflammatory response
GO:0061630 ubiquitin protein ligase activity

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000569 HECT domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR017868 Filamin/ABP280 repeat-likeRepeatRepeat
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
AREL1_HUMANHTRA2_MOUSEBioGRID23479728 details