Entity Details

Primary name ARHGB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15085
EntryNameARHGB_HUMAN
FullNameRho guanine nucleotide exchange factor 11
TaxID9606
Evidenceevidence at protein level
Length1522
SequenceStatuscomplete
DateCreated2003-08-29
DateModified2021-06-02

Ontological Relatives

GenesARHGEF11

GO terms

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GOName
GO:0001558 regulation of cell growth
GO:0001664 G protein-coupled receptor binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006941 striated muscle contraction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007266 Rho protein signal transduction
GO:0016020 membrane
GO:0030010 establishment of cell polarity
GO:0030036 actin cytoskeleton organization
GO:0043065 positive regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051056 regulation of small GTPase mediated signal transduction

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015212 Regulator of G protein signalling-like domainDomainDomain
IPR016137 RGS domainDomainDomain
IPR032919 Rho guanine nucleotide exchange factor 11FamilyFamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR036305 RGS domain superfamilyFamilyHomologous superfamily
IPR037803 Rho guanine nucleotide exchange factor 11, PH domainDomainDomain
IPR037889 Rho guanine nucleotide exchange factor 11, RGS domainDomainDomain
IPR041020 ARHGEF1-like, PH domainDomainDomain

Diseases

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Interactions

3 interactions