Entity Details

Primary name SMAD7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15105
EntryNameSMAD7_HUMAN
FullNameMothers against decapentaplegic homolog 7
TaxID9606
Evidenceevidence at protein level
Length426
SequenceStatuscomplete
DateCreated2001-05-04
DateModified2021-06-02

Ontological Relatives

GenesSMAD7

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0001650 fibrillar center
GO:0001657 ureteric bud development
GO:0002725 negative regulation of T cell cytokine production
GO:0003677 DNA binding
GO:0005518 collagen binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008013 beta-catenin binding
GO:0009653 anatomical structure morphogenesis
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010944 negative regulation of transcription by competitive promoter binding
GO:0016579 protein deubiquitination
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0022409 positive regulation of cell-cell adhesion
GO:0030154 cell differentiation
GO:0030279 negative regulation of ossification
GO:0030336 negative regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031397 negative regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032925 regulation of activin receptor signaling pathway
GO:0032991 protein-containing complex
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0034333 adherens junction assembly
GO:0034616 response to laminar fluid shear stress
GO:0034629 cellular protein-containing complex localization
GO:0034713 type I transforming growth factor beta receptor binding
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048185 activin binding
GO:0048844 artery morphogenesis
GO:0050821 protein stabilization
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0055117 regulation of cardiac muscle contraction
GO:0060373 regulation of ventricular cardiac muscle cell membrane depolarization
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060412 ventricular septum morphogenesis
GO:0070411 I-SMAD binding
GO:0071144 heteromeric SMAD protein complex
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0140416 transcription regulator inhibitor activity
GO:1902731 negative regulation of chondrocyte proliferation
GO:1903043 positive regulation of chondrocyte hypertrophy
GO:1990830 cellular response to leukemia inhibitory factor
GO:2000317 negative regulation of T-helper 17 type immune response
GO:2000320 negative regulation of T-helper 17 cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001132 SMAD domain, Dwarfin-typeDomainDomain
IPR003619 MAD homology 1, Dwarfin-typeDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR013019 MAD homology, MH1DomainDomain
IPR013790 DwarfinFamilyFamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR036578 SMAD MH1 domain superfamilyFamilyHomologous superfamily

Diseases

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