Entity Details

Primary name IKKA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15111
EntryNameIKKA_HUMAN
FullNameInhibitor of nuclear factor kappa-B kinase subunit alpha
TaxID9606
Evidenceevidence at protein level
Length745
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesCHUK

GO terms

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GOName
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0003009 skeletal muscle contraction
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007252 I-kappaB phosphorylation
GO:0007266 Rho protein signal transduction
GO:0008384 IkappaB kinase activity
GO:0008385 IkappaB kinase complex
GO:0009615 response to virus
GO:0009636 response to toxic substance
GO:0009653 anatomical structure morphogenesis
GO:0009898 cytoplasmic side of plasma membrane
GO:0010034 response to acetate
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0018105 peptidyl-serine phosphorylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032496 response to lipopolysaccharide
GO:0032727 positive regulation of interferon-alpha production
GO:0033194 response to hydroperoxide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034614 cellular response to reactive oxygen species
GO:0035631 CD40 receptor complex
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0042493 response to drug
GO:0042803 protein homodimerization activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200 response to amino acid
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051403 stress-activated MAPK cascade
GO:0061847 response to cholecystokinin
GO:0070498 interleukin-1-mediated signaling pathway
GO:0071276 cellular response to cadmium ion
GO:0071356 cellular response to tumor necrosis factor
GO:0097110 scaffold protein binding
GO:0098586 cellular response to virus
GO:1990459 transferrin receptor binding

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR022007 I-kappa-kinase-beta NEMO binding domainDomainDomain
IPR041185 IKBKB, scaffold dimerization domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00233 Aminosalicylic acidDrugbanksmall molecule
DB00244 MesalazineDrugbanksmall molecule
DB00795 SulfasalazineDrugbanksmall molecule
DB06151 AcetylcysteineDrugbanksmall molecule

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
IKKA_HUMANNOTC3_MOUSEMINT16498412 details